MSD Animal Health, 26 Talavera Rd, Macquarie Park, NSW, 2113, Australia.
Clinvet International, Uitzich Road, Bainsvlei, Bloemfontein, 9338, South Africa.
Parasit Vectors. 2018 Oct 25;11(1):557. doi: 10.1186/s13071-018-3140-x.
Dipylidium caninum is a common tapeworm of dogs contracted from ingestion of fleas containing the infective cysticercoid stage. Fluralaner is a systemically distributed isoxazoline class insecticide that delivers highly effective activity against fleas and ticks for up to 12 weeks after a single oral or topical treatment. This study evaluated the impact of this flea insecticidal efficacy on the transmission of D. caninum to dogs.
Dogs were weighed and treated with a cestocide and then randomly assigned to 3 groups of 8. Fluralaner was administered topically (at the commercial dose) to one group and orally to another group while the third received topically administered sterile water. All dogs were subsequently infested with about 100 D. caninum infected Ctenocephalides felis at 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 77 and 83 days after treatment. Visual proglottid inspections and counts were conducted daily from 35 to 113 days post-treatment. Post-treatment D. caninum incidence was calculated for each group and compared between treated and untreated groups.
All 8 dogs in the placebo-treated group became infected with D. caninum while no shed proglottids were observed at any point during the post-treatment period from any dog in either fluralaner treated group.
The insecticidal efficacy of a single treatment of either orally or topically administered fluralaner prevented D. caninum transmission from infected fleas to susceptible dogs for up to 12 weeks following administration.
犬复孔绦虫是一种常见的狗绦虫，通过摄入含有感染性囊尾蚴阶段的跳蚤而感染。氟雷拉纳是一种系统性分布的异恶唑啉类杀虫剂，单次口服或局部治疗后，对跳蚤和蜱的有效活性可长达 12 周。本研究评估了这种杀跳蚤功效对犬复孔绦虫传播的影响。
给狗称重并使用 cestocide 治疗，然后将它们随机分配到 3 组 8 只狗。一组给予氟雷拉纳局部（按商业剂量）治疗，另一组给予口服治疗，第三组给予局部给予无菌水。所有狗随后在治疗后 7、14、21、28、35、42、49、56、63、70、77 和 83 天左右用约 100 条感染了 Ctenocephalides felis 的犬复孔绦虫感染。从治疗后 35 天到 113 天，每天进行目视节片检查和计数。计算每组的治疗后犬复孔绦虫发生率，并比较治疗组和未治疗组之间的发生率。
在安慰剂治疗组的 8 只狗都感染了犬复孔绦虫，而在氟雷拉纳治疗组的任何一只狗的治疗后期间，任何时候都没有观察到脱落的节片。
口服或局部给予氟雷拉纳的单次治疗的杀虫功效可在给药后长达 12 周内防止感染的跳蚤将犬复孔绦虫传播给易感狗。
