Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab 160062, India.
Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab 160062, India.
Eur J Pharmacol. 2019 Jan 15;843:12-26. doi: 10.1016/j.ejphar.2018.10.026. Epub 2018 Oct 23.
Oxidative stress and inflammation are the mediators of diabetes and related secondary complications. Oxidative stress arises because of the excessive production of reactive oxygen species and diminished antioxidant production due to impaired Nrf2 activation, the master regulator of endogenous antioxidant. It has been established from various animal models that the transcription factor Nrf2 provides cytoprotection, ameliorates oxidative stress, inflammation and delays the progression of diabetes and its associated complications. Whereas, deletion of the transcription factor Nrf2 amplifies tissue level pathogenic alterations. In addition, Nrf2 also regulates the expression of numerous cellular defensive genes and protects against oxidative stress-mediated injuries in diabetes. The present review provides an overview on the role of Nrf2 in type 1 diabetes and explores if it could be a potential target for the treatment of diabetes and related complications. Further, the rationality of different agent's intervention has been discussed to mitigate organ damages induced by diabetes.
氧化应激和炎症是糖尿病及其相关继发性并发症的中介。氧化应激是由于活性氧（reactive oxygen species）的过度产生以及由于 Nrf2 激活受损导致抗氧化剂产生减少而引起的，Nrf2 是内源性抗氧化剂的主要调节剂。从各种动物模型中已经证实，转录因子 Nrf2 提供细胞保护、改善氧化应激、炎症并延缓糖尿病及其相关并发症的进展。然而，转录因子 Nrf2 的缺失会放大组织水平的致病改变。此外，Nrf2 还调节许多细胞防御基因的表达，并在糖尿病介导的氧化应激损伤中发挥保护作用。本综述概述了 Nrf2 在 1 型糖尿病中的作用，并探讨了它是否可能成为治疗糖尿病及其相关并发症的潜在靶点。此外，还讨论了不同药物干预的合理性，以减轻糖尿病引起的器官损伤。
