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用于增强伤口愈合过程的新兴活性氧调节技术。

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process.

作者信息

Polaka Suryanarayana, Katare Pratik, Pawar Bhakti, Vasdev Nupur, Gupta Tanisha, Rajpoot Kuldeep, Sengupta Pinaki, Tekade Rakesh Kumar

机构信息

National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India.

出版信息

ACS Omega. 2022 Aug 24;7(35):30657-30672. doi: 10.1021/acsomega.2c02675. eCollection 2022 Sep 6.

DOI:10.1021/acsomega.2c02675
PMID:36092613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9453976/
Abstract

Reactive oxygen species (ROS) is considered a double-edged sword. The slightly elevated level of ROS helps in wound healing by inhibiting microbial infection. In contrast, excessive ROS levels in the wound site show deleterious effects on wound healing by extending the inflammation phase. Understanding the ROS-mediated molecular and biomolecular mechanisms and their effect on cellular homeostasis and inflammation thus substantially improves the possibility of exogenously augmenting and manipulating wound healing with the emerging antioxidant therapeutics. This review comprehensively delves into the relationship between ROS and critical phases of wound healing and the processes underpinning antioxidant therapies. The manuscript also discusses cutting-edge antioxidant therapeutics that act via ROS scavenging to enhance chronic wound healing.

摘要

活性氧（ROS）被认为是一把双刃剑。ROS水平的轻微升高通过抑制微生物感染有助于伤口愈合。相反，伤口部位ROS水平过高会延长炎症期，对伤口愈合产生有害影响。因此，了解ROS介导的分子和生物分子机制及其对细胞稳态和炎症的影响，极大地提高了利用新兴抗氧化疗法外源性增强和调控伤口愈合的可能性。本综述全面深入地探讨了ROS与伤口愈合关键阶段之间的关系以及抗氧化疗法的基础过程。本文还讨论了通过清除ROS来促进慢性伤口愈合的前沿抗氧化疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/b36f4083aa4c/ao2c02675_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/02d66aa5e05d/ao2c02675_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/6ba954bdfd42/ao2c02675_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/5da5ff50c616/ao2c02675_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/46443c07e026/ao2c02675_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/7527a295d2a8/ao2c02675_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/d7f31226eb95/ao2c02675_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/b36f4083aa4c/ao2c02675_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/02d66aa5e05d/ao2c02675_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/6ba954bdfd42/ao2c02675_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/5da5ff50c616/ao2c02675_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/46443c07e026/ao2c02675_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/7527a295d2a8/ao2c02675_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/d7f31226eb95/ao2c02675_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71b/9453976/b36f4083aa4c/ao2c02675_0007.jpg

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本文引用的文献

[1]
analysis and tests of the tuna dark muscle hydrolysate anti-oxidation effect.

RSC Adv. 2018-4-17

[2]
Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.

Pharmacol Res. 2021-12

[3]
Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing.

Front Bioeng Biotechnol. 2021-6-24

[4]
Dopamine-Substituted Multidomain Peptide Hydrogel with Inherent Antimicrobial Activity and Antioxidant Capability for Infected Wound Healing.

ACS Appl Mater Interfaces. 2021-6-30

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A Smart Nanoplatform with Photothermal Antibacterial Capability and Antioxidant Activity for Chronic Wound Healing.

Adv Healthc Mater. 2021-7

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Int Wound J. 2022-1

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Oxid Med Cell Longev. 2021-2-27

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Beneficial Effect of Tempol, a Membrane-Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In Vitro Models.

Biomolecules. 2021-2-25

[10]
Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction.

Redox Biol. 2021-5

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