Kyoto University Hospital, Cardiology Department, 54 Shogoin Kawaramachi, Sakyo-ku, Kyoto, 606-8507, Japan.
Tokai University, Department of Medicine (Cardiology), 143 Shimokasuya, Isehara, 259-1143, Japan.
Ageing Res Rev. 2019 Jan;49:115-124. doi: 10.1016/j.arr.2018.10.006. Epub 2018 Oct 22.
Atrial fibrillation (AF) is an age-related arrhythmia, particularly affecting elderly patients. The ultimate goals in the treatment of AF are to improve prognosis and quality of life. Anticoagulants are effective for stroke prevention in AF patients, however, managing anticoagulation in elderly patients is especially challenging; requiring a comprehensive assessment of the patient and deep understanding of available therapies and doses to maximize the net benefit. This review summarizes available evidence on the efficacy and safety of anticoagulation therapy, and provides contemporary updates on the management of elderly patients with AF.
心房颤动(AF)是一种与年龄相关的心律失常,尤其影响老年患者。AF 患者治疗的最终目标是改善预后和生活质量。抗凝剂可有效预防 AF 患者的中风,但老年患者的抗凝管理极具挑战性;需要对患者进行全面评估,并深入了解可用的治疗方法和剂量,以最大限度地提高净效益。本文综述了抗凝治疗的疗效和安全性的现有证据,并就 AF 老年患者的管理提供了当代更新。