Department of Pediatrics, Hwacheon Health Center and County Hospital, Hwacheon, Korea.
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
Korean J Intern Med. 2019 May;34(3):643-650. doi: 10.3904/kjim.2018.094. Epub 2018 Oct 26.
BACKGROUND/AIMS: Despite the clinical importance anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis, risk factors for anaphylaxis, and epinephrine auto-injector (EAI) prescription status for patients with anaphylaxis remain poorly described. Thus, we investigated the prevalence of anaphylaxis and prescription rates of EAI in urban and rural areas in Korea.
We used data from the 2010 to 2014 Health Insurance Review and Assessment database. Anaphylaxis was identified through physician-certified diagnoses using the International Classification of Diseases 10th (ICD-10) codes (T780, T782, T805, T886). Data on prescription rates of EAI were collected from the Korea Orphan & Essential Drug Center, the only pharmacy exclusively dealing with EAI in Korea. The prescription rates of EAI were defined as the number of EAI prescribed against the number of patients with anaphylaxis.
The prevalence of anaphylaxis over the 5-year period was 0.023%. The annual prevalence of anaphylaxis increased over the 5-year period. Anaphylaxis was more common in males than in females (54% vs. 46%) and in the population aged 50 to 59 years old. For regional analysis, urban areas showed a relatively lower prevalence of anaphylaxis (17.3 per 100,000 individuals) along with higher prescription rates (12.0%) of EAI for patients with anaphylaxis. In contrast, rural areas showed a relatively higher prevalence of anaphylaxis (28.8 per 100,000 individuals) along with lower prescription rates (3.1%) of EAI.
The prevalence of anaphylaxis has increased annually in Korea. There were regional differences in the prevalence of anaphylaxis and prescription rates of EAI between urban and rural areas in Korea.
背景/目的：尽管过敏反应具有临床重要性，且其发生率最近有所增加，但有关过敏反应的流行病学、过敏反应的危险因素以及过敏反应患者肾上腺素自动注射器 (EAI) 处方情况的研究仍描述不足。因此，我们调查了韩国城乡地区过敏反应的流行率和 EAI 的处方率。
我们使用了 2010 年至 2014 年健康保险审查和评估数据库的数据。过敏反应通过使用国际疾病分类第 10 版 (ICD-10) 代码 (T780、T782、T805、T886) 由医生认证诊断确定。EAI 处方率的数据来自韩国孤儿和必需药物中心，该中心是韩国唯一一家专门经营 EAI 的药房。EAI 的处方率定义为开具 EAI 的数量与过敏反应患者的数量之比。
在 5 年期间，过敏反应的流行率为 0.023%。过敏反应的年流行率在 5 年内呈上升趋势。过敏反应在男性中比在女性中更常见（54%比 46%），在 50 至 59 岁年龄组中更为常见。对于区域分析，城市地区的过敏反应流行率相对较低（每 100,000 人中有 17.3 例），同时对过敏反应患者的 EAI 处方率较高（12.0%）。相比之下，农村地区的过敏反应流行率相对较高（每 100,000 人中有 28.8 例），同时 EAI 处方率较低（3.1%）。
韩国过敏反应的流行率每年都在增加。韩国城乡地区在过敏反应的流行率和 EAI 的处方率方面存在差异。
Zotero 插件
