Gwangju Science Academy, Gwangju 61005, Republic of Korea.
Jeonnam Bioindustry Foundation, Jeonnam 58275, Korea.
J Nanosci Nanotechnol. 2019 Feb 1;19(2):675-679. doi: 10.1166/jnn.2019.15910.
Bacterial iron oxide (IO) nanoparticles and doxorubicin (DOX) were complexed with lipid materials (magnetic lipocomplexes) for stimuli-sensitive drug targeting. DOX-incorporated magnetic lipocomplexes showed spherical core-shell structure with small diameter less than 300 nm, i.e., iron oxide nanoparticles were located in the inner-core of the lipocomplexes and these were surrounded by lipid bilayer. The complexe sizes were around 100 nm~300 nm while IO nanoparticle itself was smaller than 100 nm. DOX-incorporated magnetic lipocomplexes showed increased anticancer activity against CT26 mouse colorectal carcinoma cells. Stimulation with magnetic field resulted in higher cellular uptake ratio and suppression of cell growth. tumor imaging study using CT26-bearing tumor model proved that the magnet-sensitive delivery of DOX-incorporated magnetic lipocomplexes specifically suppressed the tumor growth. Magnetic lipocomplexes showed enhanced anticancer activity due to the magnet-sensitive drug delivery properties and
细菌氧化铁（IO）纳米粒子和阿霉素（DOX）与脂质材料（磁性脂质复合物）复合，用于刺激敏感的药物靶向。载 DOX 的磁性脂质复合物呈现出具有小于 300nm 直径的球形核壳结构，即氧化铁纳米粒子位于脂质复合物的内核中，这些内核被脂质双层包围。复合物的尺寸约为 100nm~300nm，而 IO 纳米粒子本身小于 100nm。载 DOX 的磁性脂质复合物对 CT26 小鼠结直肠癌细胞表现出增强的抗癌活性。磁场刺激导致更高的细胞摄取率和细胞生长抑制。使用携带 CT26 肿瘤模型的肿瘤成像研究证明，载 DOX 的磁性脂质复合物的磁敏感递药特异性地抑制了肿瘤生长。磁性脂质复合物由于磁敏感药物递药特性显示出增强的抗癌活性
