Son Jun Sik, Hwang Eun Ju, Kwon Lee Seong, Ahn Yong-Gook, Moon Byung-Kwon, Kim Jin, Kim Douk Hoon, Kim Su Gwan, Lee Sook-Young
IT-Bio Material Research Team, Korea Textile Development Institute, Daegu 41842, Korea.
Smart Medical Convergence Technology Support Center, Chosun University, Gwangju 61012, Korea.
Materials (Basel). 2021 Mar 3;14(5):1193. doi: 10.3390/ma14051193.
This study investigates the potential of propolis-embedded zeolite nanocomposites for dental implant application. Propolis-embedded zeolite nanocomposites were fabricated by complexation of propolis and zeolites. Then, they were pelleted with Poly(L-lactide) (PLA)/poly(ε-caprolactone) (PCL) polymer for the fabrication of a dental implant. The chemical properties of propolis were not changed during the fabrication of propolis-embedded zeolite nanocomposites in attenuated total reflection-fourier transform infra-red (ATR FT-IR) spectroscopy measurements. Propolis was continuously released from propolis-embedded zeolite nanocomposites over one month. PLA/PCL pellets containing propolis-embedded zeolite nanocomposites showed longer sustained release behavior compared to propolis-embedded zeolite nanocomposites. Propolis-embedded zeolite nanocomposite powder showed similar antibacterial activity against in an agar plate and formed an inhibition zone as well as chlorohexidine (CHX) powder. Eluted propolis solution from PLA/PCL pellets also maintained antibacterial activity as well as CHX solution. Furthermore, eluted propolis solution from PLA/PCL pellets showed significant antibacterial efficacy against and . Dental implants fabricated from PLA/PCl polymer and propolis-embedded zeolite nanocomposites also have antibacterial efficacy and negligible cytotoxicity against normal cells. We suggest that PLA/PCl pellets containing propolis-embedded zeolite nanocomposites are promising candidates for dental implants.
本研究调查了蜂胶包裹的沸石纳米复合材料在牙科植入物应用中的潜力。通过蜂胶与沸石的络合制备了蜂胶包裹的沸石纳米复合材料。然后，将它们与聚（L-丙交酯）（PLA）/聚（ε-己内酯）（PCL）聚合物制成颗粒，用于制造牙科植入物。在衰减全反射-傅里叶变换红外（ATR FT-IR）光谱测量中，蜂胶包裹的沸石纳米复合材料制备过程中蜂胶的化学性质未发生变化。蜂胶从蜂胶包裹的沸石纳米复合材料中持续释放超过一个月。与蜂胶包裹的沸石纳米复合材料相比，含有蜂胶包裹的沸石纳米复合材料的PLA/PCL颗粒表现出更长的缓释行为。蜂胶包裹的沸石纳米复合粉末在琼脂平板上对[具体细菌名称缺失]显示出类似的抗菌活性，并形成了抑菌圈，与洗必泰（CHX）粉末一样。从PLA/PCL颗粒中洗脱的蜂胶溶液也保持了抗菌活性，与CHX溶液一样。此外，从PLA/PCL颗粒中洗脱的蜂胶溶液对[具体细菌名称缺失]和[具体细菌名称缺失]显示出显著的抗菌效果。由PLA/PCl聚合物和蜂胶包裹的沸石纳米复合材料制成的牙科植入物对正常细胞也具有抗菌功效且细胞毒性可忽略不计。我们认为，含有蜂胶包裹的沸石纳米复合材料的PLA/PCl颗粒是牙科植入物的有前途的候选材料。
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