Wu Yanxia, Liu Weihua, Wang Rongrong, Lian Yunhe, Cheng Xinying, Yang Ruili, Wang Xianghong, Mi Si
College of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.
Chenguang Biotech Group Co., Ltd., Handan 057250, China.
Foods. 2024 Nov 21;13(23):3727. doi: 10.3390/foods13233727.
Capsaicin and quercitrin have proved to be two major ingredients in fresh chili pepper. However, the effect of these two compounds on hyperlipidemia and the related molecular mechanisms were still unclear. This work was performed to examine the hypolipidemic capacity of capsaicin and quercitrin as well as the related signaling pathways. Hyperlipidemia was induced in mice by feeding them with a high-fat diet for 4 weeks. Both capsaicin and quercitrin were beneficial to inhibit a rise in fasting glucose, total cholesterol, total triglycerides, low-density lipoprotein cholesterol, and total bile acids and to lift the level of high-density lipoprotein cholesterol in the serum. The optimal lipid-lowering data were achieved in the capsaicin and quercitrin/3:1 group. Supplementation with capsaicin and quercitrin both singly and together in the feed caused a significant influence on the metabolite profiles of mouse serum. The signaling pathway for the hypolipidemic effect of capsaicin and quercitrin was related to the down-regulation of epidermal growth factor receptor (EGFR) but the up-regulation of phosphatidylin-ositol-3-kinase (PI3K), protein kinase Bb(Akt), farnesoid X receptor 1 (FXR1), and cholesterol 7α-hydroxylase (CYP7A1). This study confirmed the jointly hypolipidemic effect of capsaicin and quercitrin, which would benefit the valorization of chili pepper resources.
辣椒素和槲皮苷已被证明是新鲜辣椒中的两种主要成分。然而，这两种化合物对高脂血症的影响及其相关分子机制仍不清楚。本研究旨在考察辣椒素和槲皮苷的降血脂能力及其相关信号通路。通过给小鼠喂食高脂饮食4周诱导高脂血症。辣椒素和槲皮苷均有助于抑制空腹血糖、总胆固醇、总甘油三酯、低密度脂蛋白胆固醇和总胆汁酸的升高，并提高血清中高密度脂蛋白胆固醇的水平。在辣椒素和槲皮苷/3:1组中获得了最佳的降脂数据。在饲料中单独或同时添加辣椒素和槲皮苷对小鼠血清代谢物谱有显著影响。辣椒素和槲皮苷降血脂作用的信号通路与表皮生长因子受体（EGFR）的下调有关，但与磷脂酰肌醇-3-激酶（PI3K）、蛋白激酶Bb（Akt）、法尼醇X受体1（FXR1）和胆固醇7α-羟化酶（CYP7A1）的上调有关。本研究证实了辣椒素和槲皮苷的联合降血脂作用，这将有利于辣椒资源的综合利用。
