Medical School of Nantong University, Nantong 226001, China.
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
Mini Rev Med Chem. 2019;19(4):272-280. doi: 10.2174/1389557518666181025151608.
Human insulin-like growth factor (IGF) axis affects the molecular pathogenesis of hepatocellular carcinoma (HCC), especially in the abnormality of hepatic IGF-I receptor (IGF-IR) or IGF-II expression as a key molecule in hepatocarcinogenesis. However, the over-expression of hepatic IGFIR is associated with HCC progression with largely unknown mechanisms. The IGF-IR as one key molecule of the IGF signal pathway plays an important role in the hepatocyte malignant transformation. Attaching importance to IGF-IR might improve the prognostic or the therapeutic technique of HCC. This article reviews IGF-IR alteration during HCC development, and the effects of silencing IGF-IR gene by specific short hairpin RNA on the inhibition of cell proliferation in vitro or HCC xenograft growth in vivo to elucidate it as a novel molecular-targeted therapy for HCC.
人胰岛素样生长因子 (IGF) 轴影响肝细胞癌 (HCC) 的分子发病机制，特别是在肝 IGF-I 受体 (IGF-IR) 或 IGF-II 表达异常作为肝癌发生的关键分子。然而，肝 IGFIR 的过度表达与 HCC 进展相关，但机制尚不清楚。IGF-IR 作为 IGF 信号通路的一个关键分子，在肝细胞恶性转化中发挥重要作用。重视 IGF-IR 可能会改善 HCC 的预后或治疗技术。本文综述了 IGF-IR 在 HCC 发展过程中的改变，以及特异性短发夹 RNA 沉默 IGF-IR 基因对体外细胞增殖或 HCC 异种移植生长的抑制作用，阐明其作为 HCC 的一种新的分子靶向治疗方法。
