激素刺激灌注大鼠肝脏后细胞外钙浓度的持续振荡
Sustained oscillations in extracellular calcium concentrations upon hormonal stimulation of perfused rat liver.
作者信息
Graf P, vom Dahl S, Sies H
出版信息
Biochem J. 1987 Feb 1;241(3):933-6. doi: 10.1042/bj2410933.
Abstract
Sustained oscillations in extracellular free Ca2+ were shown to occur on addition of vasopressin, phenylephrine or angiotensin II in isolated rat liver perfused with low (10 microM)-Ca2+ medium. The amplitude and frequency of oscillation depend on hormone concentration. In contrast, Ca2+ releases on addition of ATP, t-butyl hydroperoxide or arachidonate do not exhibit oscillatory behaviour. The vasopressin-induced oscillations were suppressed by glucagon and dibutyryl 3',5'-cyclic AMP, but not by dibutyryl 3',5'-cyclic GMP. These observations in the extracellular space complement observations by Woods, Cuthbertson & Cobbold [(1986) Nature (London) 319, 600-602] on oscillations in intracellular free Ca2+ in single liver cells.
摘要
在灌注低钙（10微摩尔）培养基的离体大鼠肝脏中，加入血管加压素、去氧肾上腺素或血管紧张素II后，细胞外游离钙离子出现持续振荡。振荡的幅度和频率取决于激素浓度。相比之下，加入ATP、叔丁基过氧化氢或花生四烯酸后钙离子释放未表现出振荡行为。血管加压素诱导的振荡被胰高血糖素和二丁酰3',5'-环磷酸腺苷抑制，但不被二丁酰3',5'-环磷酸鸟苷抑制。细胞外空间的这些观察结果补充了伍兹、卡斯伯特森和科博尔德[（1986年）《自然》（伦敦）319, 600 - 602]对单个肝细胞内游离钙离子振荡的观察结果。
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