可生物降解的磷酰二胺吗啉代寡聚物在鸡胚肿瘤模型中的抗癌药物递送能力
Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model.
作者信息
Matsumoto Kotaro, Le Hoang Doan Tan, Mai Ngoc Xuan Dat, Nakai Keigo, Komatsu Aoi, Tamanoi Fuyuhiko
机构信息
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan.
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Center for Innovative Materials and Architectures (INOMAR), University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam; Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam.
出版信息
Enzymes. 2018;44:103-116. doi: 10.1016/bs.enz.2018.09.003. Epub 2018 Oct 12.
Biodegradable PMO (Periodic Mesoporous Organosilica) has emerged as a promising type of mesoporous silica based nanoparticles for clinical translation. We as well as others have synthesized and characterized three types of nanoparticles containing disulfide, tetrasulfide or peptide-like bonds within their framework. Biodegradable PMO has high drug loading efficiency and can be taken up into cancer cells. Our experiments utilizing the chicken egg tumor model uncovered excellent capability to accumulate and deliver anticancer drugs to the tumor. These results will be described and their significance will be discussed. The chicken egg tumor model provides a convenient and versatile model for characterizing nanoparticles.
可生物降解的周期性介孔有机硅（PMO）已成为一种很有前景的基于介孔二氧化硅的纳米颗粒，有望用于临床转化。我们和其他人已经合成并表征了三种在其框架内含有二硫键、四硫键或类肽键的纳米颗粒。可生物降解的PMO具有高载药效率，并且可以被癌细胞摄取。我们利用鸡胚肿瘤模型进行的实验发现，它具有在肿瘤中积累和递送抗癌药物的卓越能力。将描述这些结果并讨论其意义。鸡胚肿瘤模型为表征纳米颗粒提供了一个方便且通用的模型。
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