Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
Faculty of Health Sciences, The University of Sydney, Australia.
Musculoskelet Sci Pract. 2019 Feb;39:170-177. doi: 10.1016/j.msksp.2018.10.001. Epub 2018 Oct 5.
Musculoskeletal conditions are common health issues with great impact on individuals. Although many factors have been associated with the development of musculoskeletal pain, such as perinatal factors, its aetiology is still poorly understood.
To systematically investigate whether perinatal factors can increase the risk of having musculoskeletal pain across the lifespan.
MEDLINE, CINAHL, Scopus, Web of Science and EMBASE databases were searched from their inception to December 2017. Descriptors used in our search strategy were related to "perinatal factors" and "musculoskeletal pain". There were no language, age, sex or date restrictions. Meta-analysis was used to pool the estimates of association between perinatal factors and musculoskeletal pain.
Among the six articles included in this systematic review, three were extracted for the meta-analysis. The pooled of three and two studies showed no association between chronic musculoskeletal pain and low birth weight (OR 1.8, 95% CI 0.9-3.8, I = 0; n = 157) or pre-term birth (OR 0.5, 95% CI 0.0-4.5; I = 78%; n = 374) in adults, respectively. Overall, the quality of evidence after applying the GRADE approach was very low across all the studies.
In adults, our meta-analysis showed no association between birth weight or pre-term birth and musculoskeletal pain, and the quality of the evidence was very low. Thus, the very low quality of evidence and limited number of studies do not suggest a direct clear association. Further high-quality longitudinal studies accounting for more relevant confounders are needed to better understand the complex mechanism that may operate between perinatal factors and musculoskeletal pain.
肌肉骨骼疾病是常见的健康问题，对个人影响很大。尽管许多因素与肌肉骨骼疼痛的发展有关，如围产期因素，但病因仍知之甚少。
系统研究围产期因素是否会增加一生中出现肌肉骨骼疼痛的风险。
从建库至 2017 年 12 月，检索 MEDLINE、CINAHL、Scopus、Web of Science 和 EMBASE 数据库。我们的检索策略中使用的描述词与“围产期因素”和“肌肉骨骼疼痛”有关。没有语言、年龄、性别或日期限制。采用荟萃分析来汇总围产期因素与肌肉骨骼疼痛之间关联的估计值。
在这项系统评价中纳入的 6 篇文章中，有 3 篇被提取用于荟萃分析。这 3 项和 2 项研究的汇总结果表明，慢性肌肉骨骼疼痛与低出生体重（OR 1.8，95%CI 0.9-3.8，I=0；n=157）或早产（OR 0.5，95%CI 0.0-4.5；I=78%；n=374）之间无关联。总体而言，应用 GRADE 方法后，所有研究的证据质量均非常低。
在成年人中，我们的荟萃分析表明，出生体重或早产与肌肉骨骼疼痛之间没有关联，证据质量非常低。因此，证据质量非常低且研究数量有限，并不能表明两者之间存在直接明确的关联。需要进一步开展高质量的、考虑更多相关混杂因素的纵向研究，以更好地理解围产期因素与肌肉骨骼疼痛之间可能存在的复杂机制。
