Oliveira Crystian B, Maher Chris G, Franco Marcia R, Kamper Steven J, Williams Christopher M, Silva Fernanda G, Pinto Rafael Z
Department of Physical Therapy, Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil.
Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Pain Med. 2020 Jun 1;21(6):1106-1121. doi: 10.1093/pm/pnz217.
To determine the magnitude of the association between cardiovascular disease and chronic musculoskeletal pain.
Systematic review with meta-analysis.
A comprehensive search was performed in five electronic databases. Population-based studies reporting the prevalence of cardiovascular diseases in adults stratified by chronic musculoskeletal pain status were considered eligible. Two independent reviewers performed the screening of the records following the inclusion criteria, extracted data, and evaluated the risk of bias of the included studies using an assessment tool of risk of bias for observational studies. In addition, we assessed the overall quality of evidence using an adaptation of the GRADE approach for prognosis.
Twenty studies were included in this review. There was high-quality evidence that people with chronic musculoskeletal pain are 1.91 times more likely to report having a cardiovascular disease compared with those without chronic musculoskeletal pain (risk ratio = 1.91, 95% confidence interval = 1.64-2.21).
Our findings demonstrated associations between chronic musculoskeletal pain and any cardiovascular diseases. Future studies are still warranted to better understand the association between chronic musculoskeletal pain and the specific types of cardiovascular diseases.
确定心血管疾病与慢性肌肉骨骼疼痛之间关联的程度。
系统评价与荟萃分析。
在五个电子数据库中进行全面检索。纳入基于人群的研究，这些研究报告了按慢性肌肉骨骼疼痛状况分层的成年人心血管疾病患病率。两名独立评审员按照纳入标准对记录进行筛选，提取数据，并使用观察性研究偏倚风险评估工具评估纳入研究的偏倚风险。此外，我们采用适用于预后的GRADE方法评估证据的总体质量。
本综述纳入了20项研究。有高质量证据表明，与没有慢性肌肉骨骼疼痛的人相比，患有慢性肌肉骨骼疼痛的人报告患心血管疾病的可能性高1.91倍（风险比=1.91，95%置信区间=1.64-2.21）。
我们的研究结果表明慢性肌肉骨骼疼痛与任何心血管疾病之间存在关联。未来仍有必要开展研究，以更好地了解慢性肌肉骨骼疼痛与特定类型心血管疾病之间的关联。
