评估肛殖距作为多囊卵巢综合征的诊断工具。
Assessment of anogenital distance as a diagnostic tool in polycystic ovary syndrome.
机构信息
Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, El Palmar Murcia 30120, Spain.
Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, El Palmar Murcia 30120, Spain; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, El Palmar Murcia 30120, Spain.
出版信息
Reprod Biomed Online. 2018 Dec;37(6):741-749. doi: 10.1016/j.rbmo.2018.08.020. Epub 2018 Oct 6.
RESEARCH QUESTION
Is anogenital distance (AGD) a useful clinical tool for predicting polycystic ovarian syndrome (PCOS) and its main National Institutes of Health (NIH) phenotypes?
DESIGN
Case-control study conducted between September 2014 and May 2016 at the Department of Obstetrics and Gynecology of the University Clinical Hospital 'Virgen de la Arrixaca' in the Murcia region (south-eastern Spain). One hundred and twenty-six cases of PCOS and 159 controls without PCOS were included. AGD measurements were taken from the anterior clitoral surface to the upper verge of the anus (AGD), and from the posterior fourchette to the upper verge of the anus (AGD). Parametric and non-parametric tests and receiver operating characteristic (ROC) curves were used to assess associations between AGD and the presence of PCOS and its phenotypes.
RESULTS
AGD, but not AGD, was associated with PCOS and all its phenotypes (P-values < 0.001 to 0.048). The highest area under the curve (0.62; 95% confidence interval 0.55 to 0.71) was obtained for all PCOS with AGD with a sensitivity and specificity of 50.0% and 73.0%, and positive and negative predictive value of 59.0% and 64.4%, respectively.
CONCLUSIONS
AGD could moderately discriminate the presence of PCOS and may be a useful clinical tool.
研究问题
肛殖距（AGD）是否可作为预测多囊卵巢综合征（PCOS）及其主要国立卫生研究院（NIH）表型的有用临床工具？
设计
2014 年 9 月至 2016 年 5 月在西班牙东南部穆尔西亚地区的大学临床医院“Virgen de la Arrixaca”妇产科进行的病例对照研究。纳入 126 例 PCOS 病例和 159 例无 PCOS 对照。从阴蒂前表面到肛门上缘（AGD）测量 AGD，并从后阴唇到肛门上缘（AGD）测量 AGD。采用参数和非参数检验和受试者工作特征（ROC）曲线评估 AGD 与 PCOS 及其表型的相关性。
结果
AGD 而非 AGD 与 PCOS 及其所有表型均相关（P 值<0.001 至 0.048）。AGD 用于所有 PCOS 的曲线下面积最高（0.62；95%置信区间 0.55 至 0.71），灵敏度和特异性分别为 50.0%和 73.0%，阳性和阴性预测值分别为 59.0%和 64.4%。
结论
AGD 可适度区分 PCOS 的存在，可能是一种有用的临床工具。
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