Liu Xishi, Ding Ding, Shen Minhong, Yan Dingmin, Guo Sun-Wei
Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Fudan University, Shanghai 200011, China.
Biomedicines. 2023 Sep 23;11(10):2618. doi: 10.3390/biomedicines11102618.
We investigated whether anogenital distance (AGD) is associated with adenomyosis, endometriosis and uterine leiomyomas (UL, also called uterine fibroids). We recruited 81 women with UL, 105 with ovarian endometrioma (OE), 116 with adenomyosis, 28 with both adenomyosis and UL, and 100 control subjects with other acquired gynecological conditions but not endometriosis, adenomyosis, UL, or polycystic ovarian syndrome. Measurements from the anterior clitoral surface to the center of the anus (AGD), from the tip of the clitoris to the center of the anus (AGD), and from the posterior fourchette to the center of the anus (AGD) were made in all subjects. Multiple regression was performed to estimate the association between AGDs and presence of OE, adenomyosis, and UL while controlling for possible confounding factors. We found that, compared with controls, women with OE and adenomyosis, but not UL, had significantly shorter AGD, but not AGD. However, the amount of variance that could be explained by the disease status is rather moderate, suggesting that factors other than disease status, bodyweight and height were also responsible for AGD. Thus, prenatal exposure to reduced levels of androgen may increase the risk of developing endometriosis and adenomyosis. However, other factors may also contribute to the pathogenesis of endometriosis and adenomyosis.
我们研究了肛殖距（AGD）是否与子宫腺肌病、子宫内膜异位症及子宫平滑肌瘤（UL，也称为子宫肌瘤）相关。我们招募了81例子宫平滑肌瘤患者、105例卵巢子宫内膜异位囊肿（OE）患者、116例子宫腺肌病患者、28例同时患有子宫腺肌病和子宫平滑肌瘤的患者，以及100例患有其他后天性妇科疾病但未患子宫内膜异位症、子宫腺肌病、子宫平滑肌瘤或多囊卵巢综合征的对照受试者。对所有受试者测量了从阴蒂前表面至肛门中心的距离（AGD）、从阴蒂尖端至肛门中心的距离（AGD）以及从后阴唇系带至肛门中心的距离（AGD）。进行多元回归以估计AGD与OE、子宫腺肌病和子宫平滑肌瘤的存在之间的关联，同时控制可能的混杂因素。我们发现，与对照组相比，患有OE和子宫腺肌病但未患子宫平滑肌瘤的女性AGD显著较短，但不是AGD。然而，疾病状态所能解释的变异量相当适中，这表明除疾病状态外，体重和身高也与AGD有关。因此，产前雄激素水平降低可能会增加患子宫内膜异位症和子宫腺肌病的风险。然而，其他因素也可能导致子宫内膜异位症和子宫腺肌病的发病机制。
