Filppi J A, Rheins M S, Klatt K
Immunology. 1977 Oct;33(4):553-9.
The influence of sulphydryl inhibitor iodoacetate on properties characteristically associated with T-lymphocytes was examined in young AKR mice. Thymocytes from mice receiving 100 microgram of iodoacetate showed a decrease in cortisone sensitivity, and responded more vigorously to phytohemagglutinin (PHA). Spleen cells from treated mice also exhibited greater reactivity to both PHA and concanavalin A (Con A). The uptake of 14C-iodoacetate by the thymus, spleen, lymph nodes, bone marrow, liver and kidneys also was investigated. One hour, 2 h and 18 h after the intraperiotoneal injection of 10-3 M iodoacetate, the thymus demonstrated a higher incorporation of the labelled compound than did the spleen, lymph nodes or other organs examined. These findings provide further evidence to indicate that the immuno-enhancement observed following iodoacetate treatment is related to its effect on T lymphocytes.
在年轻的AKR小鼠中，研究了巯基抑制剂碘乙酸对与T淋巴细胞相关的特性的影响。接受100微克碘乙酸的小鼠的胸腺细胞对可的松的敏感性降低，对植物血凝素（PHA）的反应更强烈。经处理小鼠的脾细胞对PHA和刀豆球蛋白A（Con A）也表现出更高的反应性。还研究了胸腺、脾脏、淋巴结、骨髓、肝脏和肾脏对14C-碘乙酸的摄取。腹腔注射10-3 M碘乙酸后1小时、2小时和18小时，胸腺对标记化合物的摄取高于脾脏、淋巴结或其他检查的器官。这些发现提供了进一步的证据，表明碘乙酸处理后观察到的免疫增强与其对T淋巴细胞的作用有关。
