Rheins M S, Filppi J A
J Natl Cancer Inst. 1977 May;58(5):1373-5. doi: 10.1093/jnci/58.5.1373.
Either inhibition or enhancement of the spontaneous lymphoma exhibited by AKR mice was observed after treatment with different dosages of the sulfhydryl inhibitor, sodium iodoacetate. Treatment of the mice at 3 or 6 months of age with five ip injections of 0.10 mg of iodoacetate at 5-day intervals significnatly extended the survival of the animals. A single administration of this dosage elevated the responses of splenic lymphocytes to the T-cell mitogens phytohemagglutinin (PHA) and concanavalin A (Con A), and resulted in higher PHA and Con A response ratios than were noted for age-matched controls. Conversely, groups of 3- or 6-month-old AKR mice, subjected to the same regimen but with 0.01-mg dosages, exhibited an apparent accelerated development of the leukemia and survived for significantly shorter periods. In general, splenic lymphocytes harvested from mice given a single 0.01-mg treatment of iodoacetate were not as reactive as were control cell cultures when exposed to the T-cell mitogens.
在用不同剂量的巯基抑制剂碘乙酸钠处理后，观察到AKR小鼠自发淋巴瘤的抑制或增强情况。在3或6月龄时，给小鼠腹腔注射5次，每次间隔5天，每次注射0.10毫克碘乙酸钠，显著延长了动物的存活时间。单次给予该剂量可提高脾淋巴细胞对T细胞有丝分裂原植物血凝素（PHA）和刀豆球蛋白A（Con A）的反应，并导致PHA和Con A反应率高于年龄匹配的对照组。相反，3或6月龄的AKR小鼠组，采用相同方案但剂量为0.01毫克，白血病的发展明显加速，存活时间显著缩短。一般来说，接受单次0.01毫克碘乙酸钠处理的小鼠收获的脾淋巴细胞，在暴露于T细胞有丝分裂原时，其反应性不如对照细胞培养物。
