Lo G S, Evans R H, Phillips K S, Dahlgren R R, Steinke F H
Atherosclerosis. 1987 Mar;64(1):47-54. doi: 10.1016/0021-9150(87)90053-0.
The effect of dietary fiber isolated from dehulled, defatted soybean seeds on cholesterol (CHOL) metabolism and atherosclerosis in rabbits was studied alone and in combination with isolated soy protein (ISP). Soy fiber (SF) contains both cellulosic and non-cellulosic dietary fiber. Based on the official AOAC method, soy fibers contains 75% total dietary fiber. Rabbits at 6 months of age were randomly assigned to 1 of 4 dietary treatments. All rabbits received either a casein or ISP-based diet with cellulose or SF as the only dietary fiber source for 36 weeks. Fasting blood samples and feces were collected and analyzed for lipids from individual rabbits. The entire aorta was removed and fixed, and sudanophilic stained lesions were examined visually. Rabbits consuming the SF and/or ISP diets had lower plasma CHOL levels and lower incidence of atherosclerotic lesions relative to the rabbits fed the casein-based cellulose diets. Rabbits consuming the SF and/or ISP diets also had a lower CHOL content in their liver and heart. Rabbits fed ISP-based diets had consistently increased fecal bile acid excretion, whereas rabbits fed diets containing SF had increased fecal and cholesterol concentration. These results suggest a complementary role for SF and ISP in preventing atherosclerosis in rabbits.
研究了从去皮、脱脂大豆种子中分离出的膳食纤维单独以及与分离大豆蛋白（ISP）联合使用时，对家兔胆固醇（CHOL）代谢和动脉粥样硬化的影响。大豆纤维（SF）包含纤维素和非纤维素膳食纤维。根据官方AOAC方法，大豆纤维含有75%的总膳食纤维。将6月龄的家兔随机分为4种饮食处理中的1种。所有家兔接受以酪蛋白或ISP为基础的饮食，其中纤维素或SF作为唯一的膳食纤维来源，持续36周。采集个体家兔的空腹血样和粪便，并分析其中的脂质。取出整个主动脉并固定，肉眼检查嗜苏丹染色病变。相对于喂食以酪蛋白为基础的纤维素饮食的家兔，食用SF和/或ISP饮食的家兔血浆CHOL水平较低，动脉粥样硬化病变的发生率也较低。食用SF和/或ISP饮食的家兔肝脏和心脏中的CHOL含量也较低。喂食以ISP为基础饮食的家兔粪便胆汁酸排泄持续增加，而喂食含SF饮食的家兔粪便和胆固醇浓度增加。这些结果表明SF和ISP在预防家兔动脉粥样硬化方面具有互补作用。
