凝缩蛋白的作用与压缩
Condensin action and compaction.
作者信息
Paul Matthew Robert, Hochwagen Andreas, Ercan Sevinç
机构信息
Department of Biology, New York University, New York, NY, 10003, USA.
Center for Genomics and Systems Biology, New York University, New York, NY, 10003, USA.
出版信息
Curr Genet. 2019 Apr;65(2):407-415. doi: 10.1007/s00294-018-0899-4. Epub 2018 Oct 25.
Abstract
Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.
摘要
凝聚素是一种多亚基蛋白复合体，属于染色体结构维持（SMC）复合体家族。凝聚素在包括染色体分离、基因调控、DNA修复和重组在内的广泛过程中调节染色体结构。最近的研究确定了凝聚素的结构特征和分子活性，但尚不清楚这些活性如何与归因于凝聚素的众多表型和功能相关联。在本综述中，我们简要讨论了凝聚素可能调节全局染色体压缩、拓扑相关结构域的组织、特定基因座（如tRNA基因）的聚类、rDNA分离和基因调控的不同分子机制。
相似文献
1
Condensin action and compaction.凝缩蛋白的作用与压缩
Curr Genet. 2019 Apr;65(2):407-415. doi: 10.1007/s00294-018-0899-4. Epub 2018 Oct 25.
2
Condensin Regulation of Genome Architecture.凝缩蛋白对基因组结构的调控
J Cell Physiol. 2017 Jul;232(7):1617-1625. doi: 10.1002/jcp.25702. Epub 2017 Jan 5.
3
Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2.凝聚素II通过Cap-H2的Mrg结合基序调节间期染色质组织。
G3 (Bethesda). 2015 Mar 9;5(5):803-17. doi: 10.1534/g3.115.016634.
4
Condensins and cohesins - one of these things is not like the other!凝聚素和黏合素——两者并不相同！
J Cell Sci. 2019 Feb 7;132(3):jcs220491. doi: 10.1242/jcs.220491.
5
Condensin: crafting the chromosome landscape.凝聚素：构建染色体格局。
Chromosoma. 2013 Jun;122(3):175-90. doi: 10.1007/s00412-013-0405-1. Epub 2013 Apr 2.
6
Condensin I folds the Caenorhabditis elegans genome.凝缩蛋白I折叠秀丽隐杆线虫的基因组。
Nat Genet. 2024 Aug;56(8):1737-1749. doi: 10.1038/s41588-024-01832-5. Epub 2024 Jul 22.
7
Condensins: universal organizers of chromosomes with diverse functions.凝缩素：具有多种功能的染色体通用组织者。
Genes Dev. 2012 Aug 1;26(15):1659-78. doi: 10.1101/gad.194746.112.
8
Condensin, chromatin crossbarring and chromosome condensation.凝聚素、染色质横档和染色体凝聚。
Curr Biol. 2012 Dec 4;22(23):R1012-21. doi: 10.1016/j.cub.2012.10.023.
9
Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15.在果蝇中，有丝分裂染色体压缩和同源染色体配对的维持受到凝聚素帽-H2 和其伴侣 Mrg15 的调控。
Genetics. 2013 Sep;195(1):127-46. doi: 10.1534/genetics.113.153544. Epub 2013 Jul 2.
10
Genome-wide analysis of condensin binding in Caenorhabditis elegans.秀丽隐杆线虫中凝缩蛋白结合的全基因组分析。
Genome Biol. 2013;14(10):R112. doi: 10.1186/gb-2013-14-10-r112.
引用本文的文献
1
Crossover designation recruits condensin to reorganize the meiotic chromosome axis.交叉指定招募凝聚素以重组减数分裂染色体轴。
bioRxiv. 2025 Mar 11:2020.07.16.207068. doi: 10.1101/2020.07.16.207068.
2
Different relative scalings between transient forces and thermal fluctuations tune regimes of dynamic clustering.瞬态力与热涨落之间不同的相对标度调整了动态聚集的机制。
Phys Rev E. 2025 Apr;111(4-1):044407. doi: 10.1103/PhysRevE.111.044407.
3
NCAPD3 contributes to lung cancer progression through modulated lactate-induced histone lactylation and MEK/ERK/LDHA axis.NCAPD3通过调节乳酸诱导的组蛋白乳酰化和MEK/ERK/LDHA轴促进肺癌进展。
Cancer Cell Int. 2025 May 23;25(1):189. doi: 10.1186/s12935-025-03814-x.
4
Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans.凝聚素IDC、DPY-21和CEC-4维持秀丽隐杆线虫中的X染色体抑制。
PLoS Genet. 2025 Apr 9;21(4):e1011247. doi: 10.1371/journal.pgen.1011247. eCollection 2025 Apr.
5
NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation, migration, invasion and cell cycle .NCAPD2 可作为肺腺癌的潜在预后生物标志物，促进细胞增殖、迁移、侵袭和细胞周期。
Oncol Res. 2024 Aug 23;32(9):1439-1452. doi: 10.32604/or.2024.047490. eCollection 2024.
6
Different relative scalings between transient forces and thermal fluctuations tune regimes of chromatin organization.瞬态力与热涨落之间不同的相对缩放比例调节着染色质组织的状态。
ArXiv. 2024 Jun 28:arXiv:2401.06921v2.
7
Monitoring the compaction of single DNA molecules in egg extract in real time.实时监测卵提取物中单链 DNA 分子的压缩情况。
Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2221309120. doi: 10.1073/pnas.2221309120. Epub 2023 Mar 14.
8
Fold-change of chromatin condensation in yeast is a conserved property.酵母染色质凝聚的变化倍数是一种保守特性。
Sci Rep. 2022 Oct 17;12(1):17393. doi: 10.1038/s41598-022-22340-8.
9
The yeast 2-micron plasmid Rep2 protein has Rep1-independent partitioning function.酵母 2μm 质粒 Rep2 蛋白具有 Rep1 独立的分配功能。
Nucleic Acids Res. 2022 Oct 14;50(18):10571-10585. doi: 10.1093/nar/gkac810.
10
DNA Bending Force Facilitates Z-DNA Formation under Physiological Salt Conditions.DNA 弯曲力有助于生理盐条件下 Z-DNA 的形成。
J Am Chem Soc. 2022 Jul 27;144(29):13137-13145. doi: 10.1021/jacs.2c02466. Epub 2022 Jul 15.
本文引用的文献
1
Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.凝聚素依赖性染色质紧缩在静止期全局抑制转录。
Mol Cell. 2019 Feb 7;73(3):533-546.e4. doi: 10.1016/j.molcel.2018.11.020. Epub 2018 Dec 27.
2
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape.细胞周期分辨染色质蛋白质组学揭示了有丝分裂过程中基因组调控景观的保存程度。
Nat Commun. 2018 Oct 2;9(1):4048. doi: 10.1038/s41467-018-06007-5.
3
Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription.凝聚素通过准确分离染色体而不是直接调节转录来控制细胞 RNA 水平。
Elife. 2018 Sep 19;7:e38517. doi: 10.7554/eLife.38517.
4
Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters.Smchd1 调节失活 X 染色体和 Hox 簇上的长距离染色质相互作用。
Nat Struct Mol Biol. 2018 Sep;25(9):766-777. doi: 10.1038/s41594-018-0111-z. Epub 2018 Aug 20.
5
In Vivo Evidence for ATPase-Dependent DNA Translocation by the Bacillus subtilis SMC Condensin Complex.活体内证据表明枯草芽孢杆菌 SMC 凝聚素复合物通过 ATP 酶依赖性 DNA 易位。
Mol Cell. 2018 Sep 6;71(5):841-847.e5. doi: 10.1016/j.molcel.2018.07.006. Epub 2018 Aug 9.
6
Live-Cell Imaging of Chromatin Condensation Dynamics by CRISPR.利用CRISPR对染色质凝聚动力学进行活细胞成像
iScience. 2018 Jun 29;4:216-235. doi: 10.1016/j.isci.2018.06.001. Epub 2018 Jun 5.
7
Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing.细胞核内相分离的微环境与疾病有关，并调节表观遗传状态、转录和 RNA 加工。
Semin Cell Dev Biol. 2019 Jun;90:94-103. doi: 10.1016/j.semcdb.2018.07.001. Epub 2018 Jul 25.
8
Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei.凝聚素 II 驱动果蝇核内间期染色体的大规模折叠和空间分隔。
PLoS Genet. 2018 Jul 12;14(7):e1007393. doi: 10.1371/journal.pgen.1007393. eCollection 2018 Jul.
9
Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression in .凝缩蛋白耗竭导致基因组解压缩，而不改变全局基因表达水平。
Genetics. 2018 Sep;210(1):331-344. doi: 10.1534/genetics.118.301217. Epub 2018 Jul 3.
10
Coactivator condensation at super-enhancers links phase separation and gene control.共激活因子在超级增强子上的凝聚将相分离和基因调控联系起来。
Science. 2018 Jul 27;361(6400). doi: 10.1126/science.aar3958. Epub 2018 Jun 21.
Zotero 插件