Department of Surgery, Tufts Medical Center, 800 Washington Street, South Building, 4th Floor, Boston, MA, 02111, USA.
Clinical Translational Science Program, Tufts University Sackler Graduate School, 136 Harrison Ave #813, Boston, MA, 02111, USA.
Breast Cancer Res Treat. 2019 Jan;173(2):267-274. doi: 10.1007/s10549-018-5018-1. Epub 2018 Oct 25.
PURPOSE: Breast cancer surgical techniques are evolving. Few studies have analyzed national trends for the multitude of surgical options that include partial mastectomy (PM), mastectomy without reconstruction (M), mastectomy with reconstruction (M+R), and PM with oncoplastic reconstruction (OS). We hypothesize that the use of M is declining and likely correlates with the rise of surgery with reconstructive options (M+R, OS). METHODS: A retrospective cohort analysis was conducted using the ACS-NSQIP database from 2005 to 2016 and ICD codes for IBC and DCIS. Patients were then grouped together based on current procedural terminology (CPT) codes for PM, M, M+R, and OS. In each group, categories were sorted again based on additional reconstructive procedures. Data analysis was conducted via Pearson's chi-squared test for demographics, linear regression, and a non-parametric Mann- Kendall test to assess a temporal trend. RESULTS: The patient cohort consisted of 256,398 patients from the NSQIP data base; 197,387 meet inclusion criteria diagnosed with IBC or DCIS. Annual breast surgery trends changed as follows: PM 46.3-46.1% (p = 0.21), M 35.8-26.4% (p = 0.001), M+R 15.9-23.0% (p = 0.03), and OS 1.8-4.42% (p = 0.001). Analyzing the patient cohort who underwent breast conservation, categorical analysis showed a decreased use of PM alone (96-91%) with an increased use of OS (4-9%). For the patient cohort undergoing mastectomy, M alone decreased (69-53%); M+R with muscular flap decreased (9-2%); and M+R with implant placement increased (20-40%)-all three trends p < 0.0001. CONCLUSION: The modern era of breast surgery is identified by the increasing use of reconstruction for patients undergoing breast conservation (in the form of OS) and mastectomy (in the form of M+R). Our study provides data showing significant trends that will impact the future of both breast cancer surgery and breast training programs.
目的:乳腺癌手术技术正在不断发展。很少有研究分析过多种手术选择的全国趋势,这些选择包括部分乳房切除术(PM)、乳房切除术无重建(M)、乳房切除术加重建(M+R)和 PM 加肿瘤整形重建(OS)。我们假设 M 的使用正在下降,并且可能与重建选择(M+R、OS)手术的兴起相关。
方法:我们使用美国癌症协会外科质量改进计划(ACS-NSQIP)数据库,从 2005 年至 2016 年,以及国际疾病分类代码(ICD)用于浸润性乳腺癌(IBC)和导管原位癌(DCIS)。然后,根据当前程序术语(CPT)代码将患者分为 PM、M、M+R 和 OS 组。在每个组中,根据其他重建手术再次对类别进行分类。通过 Pearson's 卡方检验进行人口统计学分析、线性回归和非参数曼-肯德尔检验来评估时间趋势。
结果:该患者队列由来自 NSQIP 数据库的 256398 名患者组成;197387 名患者符合 IBC 或 DCIS 的纳入标准。每年的乳房手术趋势变化如下:PM(46.3-46.1%)(p=0.21),M(35.8-26.4%)(p=0.001),M+R(15.9-23.0%)(p=0.03)和 OS(1.8-4.42%)(p=0.001)。分析接受乳房保留治疗的患者队列,分类分析显示单独使用 PM 的比例下降(96-91%),而 OS 的使用比例增加(4-9%)。对于接受乳房切除术的患者队列,单独使用 M 的比例下降(69-53%);带肌肉瓣的 M+R 减少(9-2%);带植入物的 M+R 增加(20-40%)-所有这三个趋势 p<0.0001。
结论:现代乳房手术时代的特点是,接受乳房保留治疗(以 OS 的形式)和乳房切除术(以 M+R 的形式)的患者越来越多地使用重建。我们的研究提供了数据,显示了将对乳腺癌手术和乳房培训计划的未来产生重大影响的显著趋势。
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