Ueda N, Yoshida A, Yokota T, Mochizuki T, Fukunishi R
Appl Pathol. 1986;4(3):179-85.
An 18-year-old woman had a 3-month history of increasing proptosis and visual loss secondary to an inferior orbital mass. Surgical exploration revealed an encapsulated mass in the orbit. After this mass was excised good vision was restored. The diagnosis of granular cell tumor was made as a result of various microscopic studies. The location of the tumor within the orbit is unusual and its histologic origin is uncertain. Immunohistochemistry by peroxidase-antiperoxidase method revealed that this tumor had S-100-protein-positive cells and negative results for lysozyme and alpha-1-antitrypsin. This fact suggests that the origin of the granular cell tumor may be due to the Schwann cell.
一名18岁女性因眶下肿物导致眼球突出和视力下降3个月。手术探查发现眼眶内有一个包膜完整的肿物。切除该肿物后视力恢复良好。通过各种显微镜检查确诊为颗粒细胞瘤。该肿瘤在眼眶内的位置不寻常，其组织学起源尚不确定。采用过氧化物酶-抗过氧化物酶法进行免疫组化显示，该肿瘤有S-100蛋白阳性细胞，溶菌酶和α-1抗胰蛋白酶检测结果为阴性。这一事实提示颗粒细胞瘤的起源可能与雪旺细胞有关。
