Planas Girón G, Tapia F J
Med Cutan Ibero Lat Am. 1986;14(2):101-8.
Three cases of granular cell myoblastoma have been studied in order to determine the presence and distribution of the S-100 specific protein in the neoplastic cells, using immunocytochemical staining techniques, through the modified avidin-biotin method. Positive immunostaining was observed in the three cases studied. The comparative study of various control cases histogenetically originating from neuroectoderm (melanoma) and specifically from Schwann cells, as also the presence of strongly positive staining in Schwann cells of peripheral nerve fibres situated inside and outside the tumor, support the concept of the neurogenic origin of this interesting tumor.
为了通过改良抗生物素蛋白-生物素方法，运用免疫细胞化学染色技术确定肿瘤细胞中S-100特异性蛋白的存在及分布情况，对3例颗粒细胞瘤进行了研究。在所研究的3例病例中均观察到了阳性免疫染色。对组织发生上源于神经外胚层（黑色素瘤）以及具体源于施万细胞的各种对照病例进行的比较研究，以及肿瘤内外周围神经纤维施万细胞中强阳性染色的存在，均支持了这种有趣肿瘤起源于神经的观点。
