拓展 5’-核苷酸酶 cN-II/NT5C2 的临床相关性。
Expanding the clinical relevance of the 5'-nucleotidase cN-II/NT5C2.
机构信息
Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Faculté Rockefeller, Centre de Recherche en Cancérologie de Lyon, 8 avenue Rockefeller, 69008, Lyon, France.
出版信息
Purinergic Signal. 2018 Dec;14(4):321-329. doi: 10.1007/s11302-018-9627-2. Epub 2018 Oct 25.
Abstract
Purine metabolism is depending on a large amount of enzymes to ensure cellular homeostasis. Among these enzymes, we have been interested in the 5'-nucleotidase cN-II and its role in cancer biology and in response of cancer cells to treatments. This protein has been cited and studied in a large number of papers published during the last decade for its involvement in non-cancerous pathologies such as hereditary spastic paraplegia, schizophrenia, and blood pressure regulation. Here, we review these articles in order to give an overview of the recently discovered clinical relevance of cN-II.
摘要
嘌呤代谢依赖于大量的酶来确保细胞内环境的稳定。在这些酶中，我们对 5'-核苷酸酶 cN-II 及其在癌症生物学和癌细胞对治疗的反应中的作用很感兴趣。由于该蛋白与非癌性疾病（如遗传性痉挛性截瘫、精神分裂症和血压调节）有关，在过去十年发表的大量论文中都引用和研究过它。在这里，我们回顾这些文章，以便概述最近发现的 cN-II 的临床相关性。
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本文引用的文献
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2
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
BMC Med Genomics. 2018 Jul 11;11(1):59. doi: 10.1186/s12920-018-0378-2.
3
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell. 2018 Jul 9;34(1):136-147.e6. doi: 10.1016/j.ccell.2018.06.003.
4
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.
Nat Commun. 2018 May 24;9(1):2047. doi: 10.1038/s41467-018-04384-5.
5
Cell-subtype-specific changes in adenosine pathways in schizophrenia.
Neuropsychopharmacology. 2018 Jul;43(8):1667-1674. doi: 10.1038/s41386-018-0028-6. Epub 2018 Feb 26.
6
Clinical and genetic spectrum of AMPD2-related pontocerebellar hypoplasia type 9.
Eur J Hum Genet. 2018 May;26(5):695-708. doi: 10.1038/s41431-018-0098-2. Epub 2018 Feb 20.
7
Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.
Brain Pathol. 2018 Nov;28(6):933-946. doi: 10.1111/bpa.12592. Epub 2018 Feb 21.
8
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.
Nature. 2018 Jan 25;553(7689):511-514. doi: 10.1038/nature25186. Epub 2018 Jan 17.
9
Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution.
Am J Hum Genet. 2017 Dec 7;101(6):925-938. doi: 10.1016/j.ajhg.2017.10.007.
10
Whole genome sequencing identifies a novel homozygous exon deletion in the gene in a family with intellectual disability and spastic paraplegia.
NPJ Genom Med. 2017;2. doi: 10.1038/s41525-017-0022-7. Epub 2017 Jun 1.
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