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中性粒细胞明胶酶相关脂质运载蛋白用于急性失代偿性心力衰竭患者急性肾损伤的早期诊断

[Neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute decompensated heart failure].

作者信息

Ledyakhova M V, Nasonova S N, Zhirov I V, Yarovaya E B, Uskach T M, Masenko V P, Tereshchenko S N

机构信息

National Medical Research Center for Cardiology.

Federal State Budgetary Educational Institution of Higher Education, "M. V. Lomonosov Moscow State University".

出版信息

Kardiologiia. 2018(S10):44-50.

PMID:30362428
Abstract

BACKGROUND

the incidence of acute kidney injury (AKI) is high in patients with acute decompensated heart failure (ADHF) and is linked with increased morbidity and mortality rates. Predictive biomarkers of AKI could allow improve outcomes in AKI.

PURPOSE

to evaluate the value of serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations for early diagnosis of AKI in patients with ADHF with left ventricular (LV) systolic function.

METHODS

we enrolled 60 men (average age was 62.0±11.1 years) hospitalized with ADHF with reduced LV systolic function (LV ejection fraction (LVEF).

摘要

背景

急性失代偿性心力衰竭(ADHF)患者急性肾损伤(AKI)的发生率很高,且与发病率和死亡率增加相关。AKI的预测生物标志物有助于改善AKI的预后。

目的

评估血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)浓度对左心室(LV)收缩功能的ADHF患者AKI早期诊断的价值。

方法

我们纳入了60名因LV收缩功能降低(LV射血分数(LVEF))而住院的ADHF男性患者(平均年龄为62.0±11.1岁)。

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