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急性失代偿性心力衰竭和急性肾损伤患者中异常miR-652-3p水平的诊断和预后意义

Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury.

作者信息

Liu Jiaolei, Zhang Hongmei, Li Xin, Wang Lin, Yu Huining, Huang Jiaohong, Liu Qingjun, Wang Chao, Jiang Aili

机构信息

Department of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.

Kidney Disease and Blood Purification Centre, The Second Hospital of Tianjin Medical University, Tianjin, China.

出版信息

J Int Med Res. 2020 Nov;48(11):300060520967829. doi: 10.1177/0300060520967829.

DOI:10.1177/0300060520967829
PMID:33249927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7708706/
Abstract

OBJECTIVE: This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p. METHODS: We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed. RESULTS: Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival. CONCLUSION: Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.

摘要

目的：本研究旨在检测一种新型微小RNA（miR-652-3p）生物标志物，以改善急性失代偿性心力衰竭（ADHF）患者急性肾损伤（AKI）的早期诊断，并评估miR-652-3p的生存预测价值。 方法：我们回顾性分析了196例ADHF患者的数据，其中65例在住院期间发生了AKI。检测血清和尿液样本中的中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平。应用实时定量PCR评估miR-652-3p mRNA表达。使用受试者工作特征曲线分析检测miR-652-3p的诊断性能。还分析了miR-652-3p的预后价值。 结果：ADHF合并AKI患者的血清和尿NGAL以及miR-652-3p水平升高。血清和尿miR-652-3p表达对预测ADHF患者AKI的发生具有诊断价值，与NGAL联合使用时诊断性能有所提高。AKI且miR-652-3p水平高的患者肾脏恢复失败率高，180天生存率低。 结论：血清和尿miR-652-3p可能是ADHF患者AKI早期诊断及AKI预后预测的候选生物标志物。NGAL和miR-652-3p联合使用可准确预测ADHF患者AKI的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/94685ffd42ac/10.1177_0300060520967829-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/daf0c7fd358e/10.1177_0300060520967829-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/98bc08009760/10.1177_0300060520967829-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/94685ffd42ac/10.1177_0300060520967829-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/daf0c7fd358e/10.1177_0300060520967829-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/98bc08009760/10.1177_0300060520967829-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8da/7708706/94685ffd42ac/10.1177_0300060520967829-fig3.jpg

相似文献

[1]
Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury.

J Int Med Res. 2020-11

[2]
Novel urinary biomarkers in detecting acute kidney injury, persistent renal impairment, and all-cause mortality following decongestive therapy in acute decompensated heart failure.

J Card Fail. 2013-9

[3]
Comparison of Neutrophil Gelatinase-Associated Lipocalin Versus B-Type Natriuretic Peptide and Cystatin C to Predict Early Acute Kidney Injury and Outcome in Patients With Acute Heart Failure.

Am J Cardiol. 2015-7-1

[4]
MicroRNA-423-5p as a biomarker for early diagnosis and outcome prediction of acute kidney injury in patients with acute decompensated heart failure.

Int J Urol. 2021-1

[5]
[Value of serum level of microRNA-494 in predicting prognosis of acute renal injury after cardiac surgery in children].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019-12

[6]
Diagnostic performance of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for acute kidney injury in an obstructive nephropathy patient.

Nephrology (Carlton). 2014-4

[7]
Assessment of biochemical markers in the early post-burn period for predicting acute kidney injury and mortality in patients with major burn injury: comparison of serum creatinine, serum cystatin-C, plasma and urine neutrophil gelatinase-associated lipocalin.

Crit Care. 2014-7-14

[8]
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis.

Am J Kidney Dis. 2009-12

[9]
Urine neutrophil gelatinase-associated lipocalin levels predict acute kidney injury in acute decompensated heart failure patients.

Ren Fail. 2015-6

[10]
[Neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute decompensated heart failure].

Kardiologiia. 2018

引用本文的文献

[1]
Roles of microRNAs in cardiorenal syndrome.

Mol Cell Biochem. 2025-3-25

[2]
The Role of MicroRNA in the Pathogenesis of Acute Kidney Injury.

Cells. 2024-9-16

[3]
miR-652-3p Suppressed the Protective Effects of Isoflurane Against Myocardial Injury in Hypoxia/Reoxygenation by Targeting ISL1.

Cardiovasc Toxicol. 2024-7

[4]
Circulating MicroRNA Profiling Identifies Distinct MicroRNA Signatures in Acute Ischemic Stroke and Transient Ischemic Attack Patients.

Int J Mol Sci. 2022-12-21

[5]
Upregulation of microRNA miR-652-3p is a prognostic risk factor for hepatocellular carcinoma and regulates cell proliferation, migration, and invasion.

Bioengineered. 2021-12

本文引用的文献

[1]
Circulating miRNA-21 as a diagnostic biomarker in elderly patients with type 2 cardiorenal syndrome.

Sci Rep. 2020-3-17

[2]
[Value of serum level of microRNA-494 in predicting prognosis of acute renal injury after cardiac surgery in children].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019-12

[3]
Acute kidney injury.

Lancet. 2019-11-23

[4]
Implication of Acute Kidney Injury in Heart Failure.

Heart Fail Clin. 2019-7-5

[5]
Acute Kidney Injury, Heart Failure, and Health Outcomes.

Cardiol Clin. 2019-5-14

[6]
MicroRNA-652-3p promotes the proliferation and invasion of the trophoblast HTR-8/SVneo cell line by targeting homeobox A9 to modulate the expression of ephrin receptor B4.

Clin Exp Pharmacol Physiol. 2019-4-1

[7]
Serum Circulating miR-150 is a Predictor of Post-Acute Myocardial Infarction Heart Failure.

Int Heart J. 2019-3-20

[8]
MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.

EBioMedicine. 2019-1-20

[9]
Circulating exosomal miR-92b-5p is a promising diagnostic biomarker of heart failure with reduced ejection fraction patients hospitalized for acute heart failure.

J Thorac Dis. 2018-11

[10]
miR-652 Promotes Tumor Proliferation and Metastasis by Targeting in Endometrial Cancer.

Mol Cancer Res. 2018-8-9

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