比索莱乌康定碱 B-D， Griffith 美丽桐中的改性埃博烷-士的宁双吲哚生物碱。
Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii.
机构信息
Hoshi University Faculty of Pharmaceutical Sciences , Hoshi University , Shinagawa, Tokyo 142-8501 , Japan.
Department of Chemistry, Faculty of Science , University Malaya , 50603 Kuala Lumpur , Malaysia.
出版信息
J Nat Prod. 2018 Nov 26;81(11):2600-2604. doi: 10.1021/acs.jnatprod.8b00749. Epub 2018 Oct 26.
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10' and C-2-O-C-9'. All compounds were deemed noncytotoxic (IC > 10 μM) when tested against A549 human lung adenocarcinoma cells.
从 Griffith 勒杜鹃的树皮中分离得到三个新的双吲哚生物碱，分别为 bisleuconothines B-D（1-3）。通过 1D 和 2D NMR 光谱和 DFT 计算阐明了它们的结构。Bisleuconothine B（1）是第一个具有 C-16-C-10'和 C-2-O-C-9'之间桥的单萜吲哚生物碱二聚体。当对 A549 人肺腺癌细胞进行测试时，所有化合物的细胞毒性均低于 10 μM（IC > 10 μM）。
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