Danilchenko Sergei N, Kalinkevich Aleksei N, Moskalenko Roman A, Kuznetsov Vladimir N, Kochenko Aleksandr V, Husak Evgenia V, Starikov Vadim V, Liu Fuyan, Meng Junhu, Lü Jinjun
Institute for Applied Physics, NAS of Ukraine, Sumy, Ukraine.
Medical Institute of Sumy State University, Sumy, Ukraine.
Interv Med Appl Sci. 2018 Jun;10(2):110-119. doi: 10.1556/1646.10.2018.24.
Thermal behavior of biological apatite is the object of several studies. Crystal size, carbonate content, phase composition, and other parameters change during annealing up to 900 °C in biological minerals with apatite structure. The way these parameters change reflects the specific properties of the initial bioapatite. This work presents data on thermal transformations of pathological bioapatite from the human cardiovascular system, namely aortic wall deposits. Some minor elements, foreign to calcium hydroxyapatite (e.g., Na and Mg), can be both incorporated in the apatite structure and localized in the surface layers of crystals, modifying functions of the mineral. A new approach was proposed to determine the predominant location of minor elements, such as Mg, Na, and K, in the mineral of pathological deposits. Mg and Na in pathological apatite can be in both structurally bound (substituting calcium in lattice) and labile (localized on the crystal surface) states, while K is not able to join the apatite structure in significant amount or be chemically bound to it. This approach, based on atomic spectrometry, can be used effectively in combination with a set of traditional techniques, such as like EDS, IRS, and XRD.
生物磷灰石的热行为是多项研究的对象。在具有磷灰石结构的生物矿物中，晶体尺寸、碳酸盐含量、相组成及其他参数在高达900°C的退火过程中会发生变化。这些参数的变化方式反映了初始生物磷灰石的特定性质。本文给出了来自人类心血管系统的病理性生物磷灰石（即主动脉壁沉积物）热转变的数据。一些对于羟基磷灰石而言属于外来的微量元素（例如Na和Mg），既可以掺入磷灰石结构中，也可以定位于晶体的表层，从而改变矿物的功能。本文提出了一种新方法来确定微量元素（如Mg、Na和K）在病理性沉积物矿物中的主要位置。病理性磷灰石中的Mg和Na可以处于结构结合态（取代晶格中的钙）和不稳定态（定位于晶体表面），而K无法大量加入磷灰石结构或与它发生化学结合。这种基于原子光谱法的方法可以与一系列传统技术（如能谱仪、红外光谱和X射线衍射）有效结合使用。
