Karabağ Turgut, Altuntaş Emіne, Kalaycı Belma, Şahіn Bahar, Somuncu Mustafa Umut, Çakır Mustafa Ozan
Faculty of Medicine, Department of Cardiology, Bulent Ecevit University, Zonguldak, Turkey.
Department of Cardiology, Ataturk State Hospital, Zonguldak, Turkey.
Interv Med Appl Sci. 2018 Jun;10(2):70-75. doi: 10.1556/1646.10.2018.20.
The objective of this study is to investigate the effect of comorbid conditions [Charlson comorbidity index (CCI)] on stent restenosis who underwent coronary angioplasty earlier.
Patients were divided into two groups; patients with critical restenosis [recurrent diameter stenosis >50% at the stent segment or its edges (5-mm segments adjacent to the stent) (Group 1; = 53, mean age: 63.8 ± 9.9 years)] and patients with no critical restenosis [<50% obstruction (Group 2; = 94, mean age: 62.1 ± 9.1 years)]. The CCI and modified CCI were used for the presence of comorbid conditions. The Gensini scoring system was used to assess the extent of coronary artery disease (CAD).
Group 1 had a significantly greater CCI and modified CCI score compared to Group 2 (7.1 ± 3.7 vs. 5.6 ± 1.6, = 0.006; 6.9 ± 3.6 vs. 4.5 ± 1.5, = 0.008, respectively). There was a weak correlation, albeit significant, between the modified CCI score and restenosis percentage ( = 0.29, < 0.001; = 0.25, = 0.003, respectively).
In conclusion, the CCI score is greater among patients with stent restenosis than those without. CCI score is higher among patients with a more diffuse CAD than with a milder disease extent.
本研究的目的是调查合并症[查尔森合并症指数（CCI）]对早期接受冠状动脉成形术患者支架再狭窄的影响。
患者分为两组；严重再狭窄患者[支架节段或其边缘（与支架相邻的5毫米节段）复发性直径狭窄>50%（第1组；n = 53，平均年龄：63.8±9.9岁）]和无严重再狭窄患者[阻塞<50%（第2组；n = 94，平均年龄：62.1±9.1岁）]。使用CCI和改良CCI来评估合并症的存在情况。采用Gensini评分系统评估冠状动脉疾病（CAD）的程度。
与第2组相比，第1组的CCI和改良CCI评分显著更高（分别为7.1±3.7对5.6±1.6，P = 0.006；6.9±3.6对4.5±1.5，P = 0.008）。改良CCI评分与再狭窄百分比之间存在弱相关性，尽管具有显著性（分别为r = 0.29，P < 0.001；r = 0.25，P = 0.003）。
总之，支架再狭窄患者的CCI评分高于无再狭窄患者。CAD更弥漫的患者的CCI评分高于疾病程度较轻的患者。
