肢体运动性失用症是帕金森病患者生活质量的独立预测指标。
Limb Kinetic Apraxia Is an Independent Predictor for Quality of Life in Parkinson's Disease.
作者信息
Vanbellingen Tim, Hofmänner Dinah, Kübel Stefanie, Bohlhalter Stephan
机构信息
Neurocenter Luzerner Kantonsspital Luzern Switzerland.
Gerontechnology and Rehabilitation Group University of Bern Bern Switzerland.
出版信息
Mov Disord Clin Pract. 2018 Jan 25;5(2):156-159. doi: 10.1002/mdc3.12572. eCollection 2018 Mar-Apr.
BACKGROUND
Impaired dexterity is a common symptom in Parkinson's disease (PD) and has been related to limb kinetic apraxia (LKA). LKA negatively influenced activities of daily living (ADL) in PD. However, the impact on quality of life (QoL) remains to be clarified, which was the aim of the current study.
METHODS
Eighty nondemented patients with PD and 60 age-matched, sex-matched healthy individuals participated in this study. The 39-item Parkinson's Disease Questionnaire was used to measure QoL. Dexterity was assessed by the coin rotation (CR) task and the ADL-related Dexterity Questionnaire 24. Nonmotor symptoms were monitored with part I of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, and motor symptoms were measured with parts II and III of the modified Movement Disorder Society-Unified Parkinson's Disease Rating Scale.
RESULTS
Regression analysis revealed that dexterity scores controlled for parkinsonian motor symptoms were a strong and independent predictor of QoL in patients with PD.
CONCLUSION
The study demonstrated that the strong association of impaired dexterity and QoL is independent of bradykinesia, thereby underscoring the clinical relevance of LKA in PD.
背景
灵活性受损是帕金森病（PD）的常见症状，与肢体运动性失用症（LKA）有关。LKA对PD患者的日常生活活动（ADL）有负面影响。然而，其对生活质量（QoL）的影响仍有待阐明，这也是本研究的目的。
方法
80例非痴呆PD患者和60名年龄、性别匹配的健康个体参与了本研究。采用39项帕金森病问卷来评估生活质量。通过硬币旋转（CR）任务和与ADL相关的灵活性问卷24来评估灵活性。使用运动障碍协会统一帕金森病评定量表第一部分监测非运动症状，使用改良的运动障碍协会统一帕金森病评定量表第二和第三部分测量运动症状。
结果
回归分析显示，在控制帕金森运动症状的情况下，灵活性得分是PD患者生活质量的一个强有力且独立的预测指标。
结论
该研究表明，灵活性受损与生活质量之间的强烈关联独立于运动迟缓，从而强调了LKA在PD中的临床相关性。
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