Fanciulli Alessandra, Goebel Georg, Metzler Bernhard, Sprenger Fabienne, Poewe Werner, Wenning Gregor K, Seppi Klaus
Department of Neurology Innsbruck Medical University Innsbruck Austria.
Department of Neuroscience Mental Health and Sensory Organs "Sapienza" University of Rome Rome Italy.
Mov Disord Clin Pract. 2015 Nov 27;3(2):156-160. doi: 10.1002/mdc3.12270. eCollection 2016 Mar-Apr.
To investigate the possible efficacy of an elastic abdominal binder to control orthostatic hypotension (OH) associated with Parkinson's disease (PD), 15 patients with PD and OH were enrolled in a single-blind crossover study with elastic abdominal versus placebo binder on two different days, separated by a 1-day interval, followed by a 4-week open-label follow-up.
Intervention significantly reduced blood pressure fall upon tilting. The mean difference (standard deviation; 95% confidence intervals) between abdominal binder versus placebo was +10 mm Hg (10.2; +3.5, +16.5; = 0.006). No significant effect on supine mean blood pressure values was observed compared to placebo ( = 0.3). Symptoms of OH decreased significantly during follow-up ( = 0.003), as assessed by means of the Orthostatic Hypotension Questionnaire.
Our findings suggest that elastic abdominal binders may be a simple complementary tool to alleviate OH in PD.
为研究弹性腹部束带控制帕金森病（PD）相关体位性低血压（OH）的可能疗效，15例PD合并OH患者参与了一项单盲交叉研究，在两个不同日期分别使用弹性腹部束带和安慰剂束带，中间间隔1天，随后进行4周的开放标签随访。
干预显著降低了倾斜时的血压下降。腹部束带与安慰剂相比的平均差异（标准差；95%置信区间）为+10 mmHg（10.2；+3.5，+16.5；P = 0.006）。与安慰剂相比，仰卧位平均血压值未观察到显著影响（P = 0.3）。通过体位性低血压问卷评估，OH症状在随访期间显著减轻（P = 0.003）。
我们的研究结果表明，弹性腹部束带可能是缓解PD患者OH的一种简单辅助工具。
