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争论仍在继续:良性还是恶性——一例腓骨多灶性上皮样血管瘤的病例报告

The debate is still open; benign or malignant: a case report of a multifocal epithelioid haemangioma of fibula.

作者信息

Rajebi Hamid, Madanipour Shahzad, Shiraj Sahar, Yegorov Arthur

机构信息

Radiology Department, SUNY Upstate Medical University, Syracuse, NY, USA.

出版信息

BJR Case Rep. 2016 May 15;2(2):20150269. doi: 10.1259/bjrcr.20150269. eCollection 2016.

DOI:10.1259/bjrcr.20150269
PMID:30363650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6180897/
Abstract

In this case, we report an epithelioid haemangioma (EH) of the fibula with ill-defined multifocal lesions and a resultant pathologic fracture. Based on radiographic appearance, these lesions were initially thought to represent a malignant process, such as primary malignant bone tumour, metastases or multiple myeloma. Osseous EHs are rare. Although they can present as multifocal lesions, the majority of bony EHs are solitary and arise in the diaphysis or metaphysis of long tubular bones, with a predilection for the lower extremity. Non-specific radiological findings, debatable cytological appearance and unpredictable clinical growth patterns commonly cause misdiagnosis of malignancy. To the best of our knowledge, a case of EH with multiple growing lesions of the fibula has not yet been reported in the literature.

摘要

在此病例中,我们报告了一例腓骨上皮样血管瘤(EH),其具有边界不清的多灶性病变并导致病理性骨折。基于影像学表现,这些病变最初被认为代表恶性过程,如原发性恶性骨肿瘤、转移瘤或多发性骨髓瘤。骨EH很罕见。尽管它们可表现为多灶性病变,但大多数骨EH是孤立性的,发生于长管状骨的骨干或干骺端,以下肢多见。非特异性的放射学表现、有争议的细胞学外观以及不可预测的临床生长模式常导致恶性肿瘤的误诊。据我们所知,文献中尚未报道过伴有腓骨多发生长性病变的EH病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/9caeb4a5212e/bjrcr.20150269.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/68876e91cc49/bjrcr.20150269.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/bca4ff73aedb/bjrcr.20150269.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/9999b46e9d89/bjrcr.20150269.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/9caeb4a5212e/bjrcr.20150269.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/68876e91cc49/bjrcr.20150269.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/bca4ff73aedb/bjrcr.20150269.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/9999b46e9d89/bjrcr.20150269.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/6180897/9caeb4a5212e/bjrcr.20150269.g004.jpg

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本文引用的文献

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Epithelioid hemangioma of bone and soft tissue: a reappraisal of a controversial entity.骨和软组织上皮样血管内皮瘤:对一个有争议实体的再评价。
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Epithelioid hemangioma of bone: a potentially metastasizing tumor?骨上皮样血管瘤:一种具有潜在转移能力的肿瘤?
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Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma.骨血管肿瘤:17例非普通血管瘤病例的研究,评估骨血管内皮瘤与上皮样血管瘤、上皮样血管内皮瘤及高级别血管肉瘤的关系。
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Epithelioid hemangioma of bone. A tumor often mistaken for low-grade angiosarcoma or malignant hemangioendothelioma.骨上皮样血管瘤。一种常被误诊为低级别血管肉瘤或恶性血管内皮瘤的肿瘤。
Am J Surg Pathol. 1993 Jun;17(6):610-7.
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Subcutaneous angiolymphoid hyperplasia with eosinophilia.伴有嗜酸性粒细胞增多的皮下血管淋巴样增生
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