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量身定制手术干预措施以治疗阻塞性睡眠呼吸暂停:一刀切并不适用。

Tailoring surgical interventions to treat obstructive sleep apnoea: one size does not fit all.

作者信息

Sethukumar Priya, Kotecha Bhik

机构信息

Otolaryngology, Head and Neck Surgery, Queen's Hospital, Romford, UK.

Royal National Throat, Nose and Ear Hospital, UCLH, London, UK.

出版信息

Breathe (Sheff). 2018 Sep;14(3):e84-e93. doi: 10.1183/20734735.020118.

Abstract

UNLABELLED

While continuous positive airway pressure (CPAP) remains the gold standard treatment of choice in patients with moderate or severe obstructive sleep apnoea (OSA), surgery has been established as a means to improve compliance and facilitate the use of CPAP, both of which are potential pitfalls in the efficacy of this treatment modality. In a minority of cases, with obvious oropharyngeal anatomical obstruction, corrective surgery may completely alleviate the need for CPAP treatment. In this review, we summarise clinical assessment, surgical options, discuss potential new treatments, and outline the importance of investigating and addressing the multiple anatomical levels that can contribute to OSA. Research into effectiveness of these procedures is rapidly accumulating, and surgery can be an effective treatment. However, given the myriad of options available and multiple levels of anatomical pathology that can present, it is imperative that correctly selected patients are matched with the most appropriate treatment for the best outcomes.

KEY POINTS

OSA is an increasingly prevalent disorder which has significant systemic effects if left untreated.Anatomical abnormalities can be corrected surgically to good effect with a growing and robust evidence base.Drug-induced sleep endoscopy is a key tool in the otolaryngologist's armamentarium to tailor specific surgery to address specific anatomical concerns, and to facilitate appropriate patient selection.Multilevel surgical approaches are often indicated instead of a "one size fits all" model.

EDUCATIONAL AIMS

To discuss how to assess patients presenting with OSA in clinic, from an otorhinolaryngology perspective.To discuss the indications for intervention.To provide an overview of nonsurgical interventions for treating OSA, with evidence.To discuss the different surgical modalities available for treatment of OSA, with evidence.

摘要

未标注

虽然持续气道正压通气(CPAP)仍然是中度或重度阻塞性睡眠呼吸暂停(OSA)患者的金标准治疗选择,但手术已被确立为一种改善依从性并促进CPAP使用的方法,而这两者都是这种治疗方式疗效的潜在陷阱。在少数情况下,对于明显的口咽解剖学阻塞,矫正手术可能完全消除对CPAP治疗的需求。在本综述中,我们总结了临床评估、手术选择,讨论了潜在的新治疗方法,并概述了研究和解决可能导致OSA的多个解剖层面问题的重要性。对这些手术有效性的研究正在迅速积累,手术可以是一种有效的治疗方法。然而,鉴于有众多可用的选择以及可能出现的多个解剖病理学层面,正确选择患者并为其匹配最合适的治疗方法以获得最佳结果至关重要。

关键点

OSA是一种日益普遍的疾病,如果不治疗会产生重大的全身影响。解剖学异常可以通过手术得到有效矫正,且证据基础不断扩大和充实。药物诱导睡眠内镜检查是耳鼻喉科医生的重要工具,可据此定制特定手术以解决特定的解剖学问题,并有助于进行合适的患者选择。通常需要采用多层面手术方法,而不是“一刀切”的模式。

教育目标

从耳鼻喉科角度讨论如何在诊所评估OSA患者。讨论干预的适应症。提供治疗OSA的非手术干预措施概述及证据。讨论可用于治疗OSA的不同手术方式及证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a2/6196320/2444a209cbed/EDU-0201-2018.01.jpg

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