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Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications.

作者信息

DiNicolantonio James J, McCarty Mark F, O'Keefe James H

机构信息

Department of Preventive Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.

Catalytic Longevity, San Diego, California, USA.

出版信息

Open Heart. 2018 Oct 16;5(2):e000914. doi: 10.1136/openhrt-2018-000914. eCollection 2018.

DOI:10.1136/openhrt-2018-000914
PMID:30364545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6196942/
Abstract
摘要

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Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?胆红素升高是否通过预防下丘脑瘦素抵抗的发展来帮助控制体重？
Open Heart. 2019 Mar 22;6(1):e000897. doi: 10.1136/openhrt-2018-000897. eCollection 2019.
2
Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV-Positive and HIV-Negative Individuals in VACS (Veterans Aging Cohort Study).在 VACS（退伍军人老龄化队列研究）中，胆红素与 HIV 阳性和 HIV 阴性个体的心血管疾病呈负相关。
J Am Heart Assoc. 2018 May 2;7(10):e007792. doi: 10.1161/JAHA.117.007792.
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Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.过氧亚硝酸盐的生物化学与蛋白质酪氨酸硝化。
Chem Rev. 2018 Feb 14;118(3):1338-1408. doi: 10.1021/acs.chemrev.7b00568. Epub 2018 Feb 5.
4
[The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction].[活性氧在代谢综合征中脂肪细胞功能障碍发病机制中的作用。药物纠正的前景]
Vestn Ross Akad Med Nauk. 2017;72(1):11-6. doi: 10.15690/vramn798.
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Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.轻度高胆红素血症作为超重和肥胖的内源性缓解因素：对改善代谢健康的影响。
Atherosclerosis. 2018 Feb;269:306-311. doi: 10.1016/j.atherosclerosis.2017.12.021. Epub 2017 Dec 14.
6
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex.促炎型肝巨噬细胞通过内吞单体 TLR4-MD2 复合物，通过 NADPH 氧化酶 2 产生 ROS。
Nat Commun. 2017 Dec 21;8(1):2247. doi: 10.1038/s41467-017-02325-2.
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NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?NADPH 氧化酶作为神经退行性疾病的药物靶点和生物标志物：有何证据？
Free Radic Biol Med. 2017 Nov;112:387-396. doi: 10.1016/j.freeradbiomed.2017.08.006. Epub 2017 Aug 12.
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Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction.脂联素，肥胖、糖尿病及内皮功能障碍的治疗靶点。
Int J Mol Sci. 2017 Jun 21;18(6):1321. doi: 10.3390/ijms18061321.
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Bilirubin and atherosclerotic diseases.胆红素与动脉粥样硬化性疾病。
Physiol Res. 2017 Apr 5;66(Suppl 1):S11-S20. doi: 10.33549/physiolres.933581.