轻度高胆红素血症作为超重和肥胖的内源性缓解因素：对改善代谢健康的影响。
Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
机构信息
University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstraße 14 (UZA2), 1090, Vienna, Austria.
University of Applied Sciences, FH JOANNEUM, Institute of Dietetics and Nutrition, Alte Poststraße 149, 8020, Graz, Austria.
出版信息
Atherosclerosis. 2018 Feb;269:306-311. doi: 10.1016/j.atherosclerosis.2017.12.021. Epub 2017 Dec 14.
BACKGROUND AND AIMS
Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile.
METHODS
Our study considered GS and age-/gender-matched healthy controls (n = 248). Additionally, obese female type 2 diabetic patients (DM2) (n = 26) were included as a "disease control group".
RESULTS
BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile.
CONCLUSIONS
Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.
背景与目的
吉尔伯特综合征（GS）患者体内出现的未结合胆红素（UCB）轻度内源性升高，可能减轻包括超重/肥胖在内的心血管疾病（CVD）危险因素。本研究旨在确定高胆红素血症是否与改善人体测量数据和血脂谱有关。
方法
我们的研究考虑了 GS 患者和年龄/性别匹配的健康对照组（n=248）。此外，还纳入了肥胖的 2 型糖尿病女性患者（DM2）（n=26）作为“疾病对照组”。
结果
GS 患者的 BMI、臀围（HC）和血脂谱明显较低。UCB 与 BMI（p<0.001）、HC 以及脂肪量（FM）和血脂变量呈负相关（p<0.05）。此外，与 GS 患者和健康对照组相比，DM2 患者的 UCB 明显较低。年龄较大的 GS 患者（≥35 岁）的人体测量数据明显减少，血脂谱得到改善。
结论
我们的研究结果表明，轻度高胆红素血症的促进健康的潜力可能延伸到预防与年龄相关的体重增加和血脂异常。
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