Lewis J A, Bendicenti di Girolamo A
FEBS Lett. 1987 Jun 15;217(2):292-6. doi: 10.1016/0014-5793(87)80681-6.
A mouse cell line (Ltk-aprt-) which is resistant to the anti-viral effects of interferon also has a reduced ability to synthesize metallothionein on exposure to cadmium. Like the ability to respond to interferon, cadmium-induced metallothionein synthesis is restored to wild-type levels in clones obtained by introducing a thymidine kinase gene into Ltk-aprt-cells. Transfection of other genes does not have such an effect. Since metallothionein expression is also activated by interferon the results suggest that the regulation of several genes which are responsive to interferon can be modulated by specific sequences present in the Herpes virus thymidine kinase gene.
一种对干扰素抗病毒作用具有抗性的小鼠细胞系（Ltk-aprt-）在接触镉时合成金属硫蛋白的能力也有所降低。与对干扰素的反应能力一样，通过将胸苷激酶基因导入Ltk-aprt-细胞而获得的克隆中，镉诱导的金属硫蛋白合成恢复到了野生型水平。转染其他基因则没有这种效果。由于金属硫蛋白的表达也受到干扰素的激活，因此结果表明，对干扰素产生反应的几个基因的调控可被疱疹病毒胸苷激酶基因中存在的特定序列所调节。
