Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan; Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan.
Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan.
J Chem Neuroanat. 2018 Dec;94:125-138. doi: 10.1016/j.jchemneu.2018.10.001. Epub 2018 Oct 24.
Myostatin (also called as growth and differentiation factor 8 or GDF8), a member of the transforming growth factor β (TGF-β) superfamily of secreted differentiation and growth factors, is a potent inhibitor of skeletal muscle mass in mammals. Although myostatin also plays pivotal roles in cardiac growth and metabolism, postnatal glucose metabolism and adipogenesis, little information is available for myostatin function in the adult central nervous system (CNS). We, thus, investigated myostatin expression in the adult rat CNS using immunohistochemistry. Myostatin was intensely expressed in most neurons and their axons. Furthermore, we found that oligodendrocytes, astrocytes and ependymal cells also express myostatin protein. These data indicate that myostatin is widely expressed throughout the adult CNS, and its abundant expression in the adult brain suggests the idea that myostatin plays important roles in the CNS.
肌肉生长抑制素（也称为生长分化因子 8 或 GDF8），是转化生长因子 β（TGF-β）超家族分泌的分化和生长因子的成员，是哺乳动物骨骼肌质量的有效抑制剂。尽管肌肉生长抑制素在心脏生长和代谢、出生后葡萄糖代谢和脂肪生成中也起着关键作用，但关于肌肉生长抑制素在成年中枢神经系统（CNS）中的功能的信息很少。因此，我们使用免疫组织化学方法研究了成年大鼠中枢神经系统中的肌肉生长抑制素表达。肌肉生长抑制素在大多数神经元及其轴突中强烈表达。此外，我们发现少突胶质细胞、星形胶质细胞和室管膜细胞也表达肌肉生长抑制素蛋白。这些数据表明，肌肉生长抑制素在整个成年中枢神经系统中广泛表达，其在成年大脑中的大量表达表明肌肉生长抑制素在中枢神经系统中发挥重要作用的观点。
