Ogawa Chikara, Mikawa Sumiko, Li Shuo, Hayashi Yutaro, Masumoto Kazuma, Sato Kohji
Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan; Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
J Chem Neuroanat. 2022 Apr;121:102084. doi: 10.1016/j.jchemneu.2022.102084. Epub 2022 Feb 16.
Bone morphogenetic protein 10 (BMP10), is a member of the transforming growth factor β (TGFβ) superfamily. Although BMP10 plays pivotal roles during development, including vascular development and cardiogenesis, little information is available for BMP10 expression in the central nervous system (CNS). We, thus, investigated BMP10 expression in the adult rat CNS using immunohistochemistry. BMP10 was intensely expressed in most neurons and their axons. Furthermore, we found that astrocytes and ependymal cells also express BMP10 protein. These data indicate that BMP10 is widely expressed throughout the adult CNS, and this abundant expression strongly supports the idea that BMP10 also plays important roles in the adult CNS.
骨形态发生蛋白10（BMP10）是转化生长因子β（TGFβ）超家族的成员。尽管BMP10在发育过程中发挥着关键作用，包括血管发育和心脏发生，但关于BMP10在中枢神经系统（CNS）中的表达情况知之甚少。因此，我们使用免疫组织化学方法研究了成年大鼠中枢神经系统中BMP10的表达。BMP10在大多数神经元及其轴突中强烈表达。此外，我们发现星形胶质细胞和室管膜细胞也表达BMP10蛋白。这些数据表明，BMP10在整个成年中枢神经系统中广泛表达，这种丰富的表达有力地支持了BMP10在成年中枢神经系统中也发挥重要作用的观点。
