D-半乳糖胺诱导大鼠肝细胞膜脂质组成和某些酶活性发生变化。

D-galactosamine induced changes in rat liver plasma membranes lipid composition and some enzyme activities.

作者信息

Petkova D H, Momchilova A B, Markovska T T, Koumanov K S

出版信息

Int J Biochem. 1987;19(3):289-91. doi: 10.1016/0020-711x(87)90034-6.

Abstract

The influence of D-galactosamine administration on rat liver plasma membranes lipid composition, fluidity and some enzyme activities was investigated. D-Galactosamine was found to induce an increase of the total phospholipids, the cholesterol level and membrane rigidity. In liver plasma membranes of D-galactosamine-treated rats the exogenous phospholipase A2 activity was enhanced about 2 fold, whereas the endogenous activity was slightly decreased. No alteration of the neutral sphingomyelinase activity was observed.

摘要

研究了给予D-半乳糖胺对大鼠肝质膜脂质组成、流动性和一些酶活性的影响。发现D-半乳糖胺可导致总磷脂、胆固醇水平升高以及膜刚性增加。在经D-半乳糖胺处理的大鼠的肝质膜中，外源性磷脂酶A2活性增强了约2倍，而内源性活性略有下降。未观察到中性鞘磷脂酶活性的改变。