State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029 Beijing, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029 Beijing, China; Chair of Materials Science (CMS), Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena, Germany.
J Colloid Interface Sci. 2019 Feb 15;536:160-170. doi: 10.1016/j.jcis.2018.10.050. Epub 2018 Oct 19.
For personalized cancer treatment, developing smart biomaterials with multiple biological functions is indispensable in nanomedicine fields. In this work, we developed a highly efficient near-infrared- (NIR-) and pH-responsive carboxymethyl chitosan-functionalized reduced graphene oxide/aldehyde functionalized poly (ethylene glycol) (CMC-rGO/CHO-PEG) hydrogel, which exhibits outstanding delivery performance of antitumor drug, doxorubicin hydrochloride (DOX). CMC was functionalized on the GO nanosheets via a controllable approach in order to achieve strong NIR absorption property and good distribution of rGO. The intercalation effect of CMC-rGO complex improved rGO distribution in the 3D hydrogel, contributing to the enhanced photothermal performance of CMC-rGO/CHO-PEG hydrogel. Furthermore, potential utilization of these CMC-rGO/CHO-PEG hydrogel for drug loading was studied, which provided pH-sensitive release of DOX payload. Particularly, DOX could be released in a more efficient way under acidic environment (pH = 6.5) than that under physiological environment (pH = 7.4). Therefore, this rGO hybridized PEG hydrogel holds strategic potential as a novel drug release platform for combined chem-photothermal therapy.
对于个性化癌症治疗，在纳米医学领域开发具有多种生物学功能的智能生物材料是必不可少的。在这项工作中，我们开发了一种高效的近红外（NIR）和 pH 响应的羧甲基壳聚糖功能化还原氧化石墨烯/醛基功能化聚乙二醇（CMC-rGO/CHO-PEG）水凝胶，该水凝胶对盐酸阿霉素（DOX）等抗肿瘤药物具有出色的输送性能。通过可控方法将 CMC 功能化在 GO 纳米片上，以实现强 NIR 吸收特性和 rGO 的良好分布。CMC-rGO 复合物的插层效应改善了 rGO 在 3D 水凝胶中的分布，有助于增强 CMC-rGO/CHO-PEG 水凝胶的光热性能。此外，还研究了这些 CMC-rGO/CHO-PEG 水凝胶在药物负载方面的潜在应用，这为 DOX 有效载药提供了 pH 敏感释放。特别是，在酸性环境（pH=6.5）下，DOX 的释放效率要高于生理环境（pH=7.4）。因此，这种 rGO 杂化 PEG 水凝胶作为一种新型的联合化学-光热治疗药物释放平台具有重要的战略意义。
