Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.
Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.
Carbohydr Polym. 2019 Jan 15;204:32-41. doi: 10.1016/j.carbpol.2018.09.084. Epub 2018 Oct 2.
The aim of this work was to obtain a novel onco-theranostic system for early diagnosis and improved chemotherapeutic outcome. Hybrid nanogels with magnetic and dual responsive properties were fabricated by covalently attaching superparamagnetic iron oxide nanoparticles (SPIONs) with a disulfide-modified alginate derivative, while simultaneously encapsulating the anticancer drug doxorubicin. The resulting nanogels exhibited magnetic-targeted characteristics, high drug loading content, co-triggered release behavior, high toxicity to tumor cells, low side effects to normal cells, and magnetic resonance imaging (MRI) functions. These findings proved that the hybrid nanogels have great potential as novel tumor-targeting nano-theranostic agents for simultaneous MRI imaging and efficient anti-tumor treatment.
本工作旨在获得一种新型的治疗肿瘤的诊断和治疗系统，以实现早期诊断和改善化疗效果。通过将超顺磁性氧化铁纳米粒子（SPIONs）与巯基化海藻酸钠衍生物共价连接，同时包封抗癌药物阿霉素，制备了具有磁性和双重响应特性的杂化纳米凝胶。所得纳米凝胶表现出磁靶向特性、高药物载量、共触发释放行为、对肿瘤细胞的高毒性、对正常细胞的低副作用和磁共振成像（MRI）功能。这些发现证明，杂化纳米凝胶具有作为新型肿瘤靶向纳米治疗剂的巨大潜力，可用于同时进行 MRI 成像和高效抗肿瘤治疗。
