进行性多灶性白质脑病。
Progressive Multifocal Leukoencephalopathy.
机构信息
Multiple Sclerosis Division, Davee Department of Neurology, Northwestern University Feinberg School of Medicine, 675 St. Clair, Chicago, IL 60611, USA.
Multiple Sclerosis Division, The Department of Neurology, Perelman School of Medicine, The University of Pennsylvania, 3400 Convention Avenue, Philadelphia, PA 19104, USA.
出版信息
Neurol Clin. 2018 Nov;36(4):739-750. doi: 10.1016/j.ncl.2018.06.002.
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.
进行性多灶性白质脑病（PML）是一种罕见的机会性感染，发生于免疫系统受损的患者，原因可能是基础疾病或免疫抑制药物。60%或更多的成年人存在潜伏或持续的JC 病毒感染，该病毒是 PML 综合征的致病原因。本文综述了与最常见免疫疗法相关的 PML，并讨论了风险缓解和监测策略。
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