在患有 CF 的女性中，无法怀孕与胰腺功能不全和年龄增长有关。

Failure to conceive in women with CF is associated with pancreatic insufficiency and advancing age.

机构信息

Pulmonology Institute, Carmel Medical Center, Israel; Cystic Fibrosis Center, Carmel Medical Center, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.

出版信息

J Cyst Fibros. 2019 Jul;18(4):525-529. doi: 10.1016/j.jcf.2018.10.009. Epub 2018 Oct 23.

DOI:10.1016/j.jcf.2018.10.009

PMID:30366850

Abstract

OBJECTIVE

The causes of subfertility in women with CF though multifactorial are not well described. Our aim in this study was to determine the prevalence and factors associated with female subfertility among women with CF.

METHODS

A retrospective multinational study from 11 CF centers in 5 countries (Israel, France, Spain, Italy, UK) including women with CF was undertaken. Sub/infertility was defined as not achieving a spontaneous pregnancy after one year of unprotected sexual intercourse. Data including genetics, pancreatic insufficiency (PI), prevalence of diabetes (CFRD), lung function, nutritional status measured by body mass index (BMI), sputum bacterial colonization, and rate of pulmonary exacerbations were collected from patients' files.

RESULTS

Out of 605 women, 241 attempted pregnancy. Of these, 84 (35%) had subfertility, and 67 of them eventually became pregnant. Females attempting conception were older but had better pulmonary function and nutrition compared to those who did not. In a multivariate analysis, PI (OR 1.9 [1.03-3.5], p = .04) and older age (OR 3.9 [2.1-7.3] p < .0001) were associated with subfertility. Lung function, BMI, CFRD, Presence of two class I-III mutations and number of exacerbations in the year prior to fertility attempts were not associated with subfertility.

CONCLUSIONS

The prevalence of subfertility among women with CF (35%) is higher than the expected 5-15% subfertility in the general population. Older age and pancreatic insufficiency are associated with subfertility in women with CF.

摘要

目的

尽管 CF 女性不孕的原因是多因素的，但并未得到很好的描述。我们本研究的目的是确定 CF 女性中女性不孕的患病率和相关因素。

方法

这项来自 5 个国家（以色列、法国、西班牙、意大利、英国）的 11 个 CF 中心的回顾性多国研究纳入了 CF 女性。亚/不孕定义为无保护性行为一年后未自然怀孕。从患者档案中收集了包括遗传学、胰腺功能不全 (PI)、糖尿病患病率 (CFRD)、肺功能、通过体重指数 (BMI) 测量的营养状况、痰细菌定植和肺部恶化率等数据。

结果

在 605 名女性中，有 241 名尝试怀孕。其中 84 名（35%）有生育力低下，其中 67 名最终怀孕。尝试怀孕的女性年龄较大，但肺功能和营养状况较好。在多变量分析中，PI（OR 1.9 [1.03-3.5]，p=0.04）和年龄较大（OR 3.9 [2.1-7.3]，p<0.0001）与生育力低下相关。肺功能、BMI、CFRD、前一年有 2 个 I-III 类突变和恶化次数与生育力低下无关。