Barrow Neurological Institute, Phoenix, AZ, USA.
Department of Neurosurgery, University of Münster, Münster, Germany.
J Neurooncol. 2019 Jan;141(1):13-18. doi: 10.1007/s11060-018-03026-6. Epub 2018 Oct 26.
Fluorescence guided surgery has developed over the last 2 decades as a formidable augmentation strategy to promote maximal safe resection and diagnostic accuracy within gliomas. The majority of the literature evidence supporting this modality utilizes 5-aminolevulinic acid in the setting of high-grade gliomas. The role for fluorescence guided surgery in low-grade gliomas is less well defined.
This review describes the existing literature discussing the utilization of 5-aminolevulinic acid for fluorescence guided surgery in low-grade gliomas, including its pertinence in identification of anaplastic foci and potential role in guiding resection following combination with augmentation strategies for detection.
The advance in operative technology and growth of research analyzing 5-aminolevulinic acid will continue to enhance the role of fluorescence guided surgery within the standard of surgical management for low-grade gliomas.
荧光引导手术在过去的 20 年中得到了发展，成为一种强大的辅助策略，以提高胶质瘤中的最大安全切除和诊断准确性。支持这种方式的大多数文献证据都利用了 5-氨基乙酰丙酸在高级别胶质瘤中的应用。荧光引导手术在低级别胶质瘤中的作用则不太明确。
本文回顾了现有的文献，讨论了 5-氨基乙酰丙酸在低级别胶质瘤中荧光引导手术的应用，包括其在识别间变病灶中的相关性，以及在与检测增强策略结合后指导切除的潜在作用。
随着手术技术的进步和分析 5-氨基乙酰丙酸的研究的发展，荧光引导手术在低级别胶质瘤的手术治疗标准中的作用将不断增强。
