Carzaniga Tommaso Stefano, Braccini Saverio
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Appl Radiat Isot. 2019 Jan;143:18-23. doi: 10.1016/j.apradiso.2018.10.015. Epub 2018 Oct 15.
Novel medical radioisotopes for both diagnostic and therapy are essential for the future development of personalized nuclear medicine. Among them, radiometals can be used to label both proteins and peptides and encompass promising theranostic pairs. The optimized supply of radiometals in quantity and quality for clinical applications represents a scientific and technological challenge. Sc is a β emitter that forms a theranostic pair together with one of the β emitters Sc or Sc. It can be produced at a medical cyclotron by proton bombardment of an enriched calcium oxide target. The parasite production of Sc undermines the Sc purity, which strongly depends on the energy of protons impinging the target and on the thickness of the target material. For this purpose, an accurate knowledge of the production cross-sections is mandatory. In this paper, we report on the measurement of the cross-section of the reactions Ca(p,n)Sc,Ca(p,n)Sc, Ca(p,2n)Sc and Ca(p,pn)Ca using CaCO targets performed at the Bern University Hospital cyclotron laboratory. On the basis of the obtained results and of the isotopic composition of commercially available enriched target materials, the thick target yields and the purity were calculated to assess the optimal irradiation conditions.
新型的用于诊断和治疗的医用放射性同位素对于个性化核医学的未来发展至关重要。其中，放射性金属可用于标记蛋白质和肽，并包含有前景的诊疗组合。为临床应用提供数量和质量均优化的放射性金属是一项科技挑战。钪是一种β发射体，它与另一种β发射体钪或钪形成诊疗组合。它可在医用回旋加速器中通过用质子轰击富集的氧化钙靶来生产。钪的寄生产物会破坏钪的纯度，而钪的纯度很大程度上取决于撞击靶的质子能量以及靶材料的厚度。为此，必须准确了解生产截面。在本文中，我们报告了在伯尔尼大学医院回旋加速器实验室使用碳酸钙靶对反应Ca(p,n)钪、Ca(p,n)钪、Ca(p,2n)钪和Ca(p,pn)钙的截面进行的测量。根据获得的结果以及市售富集靶材料的同位素组成，计算了厚靶产率和纯度，以评估最佳辐照条件。
