Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Appl Radiat Isot. 2022 Aug;186:110252. doi: 10.1016/j.apradiso.2022.110252. Epub 2022 Apr 26.
The future development of personalized nuclear medicine relies on the availability of novel medical radionuclides. In particular, radiometals are attracting considerable interest since they can be used to label both proteins and peptides. Among them, the β-emitter Ga is widely used in nuclear medicine for positron emission tomography (PET). It is used in theranostics as the diagnostic partner of the therapeutic β-emitters Lu and Y for the treatment of a wide range of diseases, including prostate cancer. Currently, Ga is usually obtained via Ge/Ga generators. However, their availability, high price and limited produced radioactivity per elution are a major barrier for a wider use of the Ga-based diagnostic radiotracers. A promising solution is the production of Ga by means of proton irradiation of enriched Zn liquid or solid targets. Along this line, a research program is ongoing at the Bern medical cyclotron, equipped with a solid target station. In this paper, we report on the measurements of Ga, Ga and Ga production cross-sections using natural Zn and enriched Zn material, which served as the basis to perform optimized Ga production tests with enriched Zn solid targets.
个性化核医学的未来发展依赖于新型医用放射性核素的可用性。特别是放射性金属因其可用于标记蛋白质和肽而受到广泛关注。其中，β发射器 Ga 广泛用于正电子发射断层扫描 (PET) 核医学。它作为治疗性β发射器 Lu 和 Y 的诊断伴侣用于治疗包括前列腺癌在内的多种疾病的治疗。目前，Ga 通常通过 Ge/Ga 发生器获得。然而，它们的可用性、高价格和每次洗脱的有限放射性活度是广泛使用基于 Ga 的诊断放射性示踪剂的主要障碍。一种有前途的解决方案是通过质子辐照富锌液体或固体靶来生产 Ga。沿着这条线，伯尔尼医用回旋加速器正在进行一个研究计划，该回旋加速器配备了一个固体靶站。在本文中，我们报告了使用天然 Zn 和富 Zn 材料测量 Ga、Ga 和 Ga 生产截面的情况，这为使用富 Zn 固体靶进行优化的 Ga 生产测试提供了依据。
