Dellepiane Gaia, Casolaro Pierluigi, Favaretto Chiara, Grundler Pascal V, Mateu Isidre, Scampoli Paola, Talip Zeynep, van der Meulen Nicholas P, Braccini Saverio
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Appl Radiat Isot. 2022 Jun;184:110175. doi: 10.1016/j.apradiso.2022.110175. Epub 2022 Mar 9.
Tb [t = 5.32 d, E = 87 keV (32%); 105 keV (25%) (IAEA, 2021)] is a novel promising radionuclide for theranostic applications in nuclear medicine. Its physical properties make it suitable for single photon emission computed tomography (SPECT) imaging, while its chemistry allows it to be used as a diagnostic partner for therapeutic radiolanthanides or pseudo-radiolanthanides, such as Lu and Y. Moreover, Tb could be used as a precise diagnostic match for the β-emitter Tb, opening doors for the true theranostics concept. The availability of Tb in quantity and quality suitable for medical applications is an open issue and its production with medical cyclotrons via the Gd(p,n)Tb and Gd(p,2n)Tb nuclear reactions represents a possible but challenging solution. For this purpose, an accurate knowledge of the production cross sections is mandatory. In this paper, we report on the measurement of the production cross sections of Tb and other terbium radionuclides formed by proton irradiation of GdO, GdO and GdO enriched targets, performed at the Bern University Hospital cyclotron laboratory. On the basis of the obtained results, the production yield and purity were calculated to assess the optimal irradiation conditions. The results of several production tests are also presented.
铽（Tb）[半衰期t = 5.32天，能量E = 87 keV（32%）；105 keV（25%）（国际原子能机构，2021年）]是一种在核医学诊疗应用中颇具前景的新型放射性核素。其物理性质使其适用于单光子发射计算机断层扫描（SPECT）成像，而其化学性质则允许它用作治疗性放射性镧系元素或类放射性镧系元素（如镥和钇）的诊断搭档。此外，铽可作为β发射体铽的精确诊断匹配物，为真正的诊疗一体化概念打开大门。获得数量和质量均适合医学应用的铽是一个悬而未决的问题，通过Gd(p,n)Tb和Gd(p,2n)Tb核反应利用医用回旋加速器生产铽是一种可能但具有挑战性的解决方案。为此，必须准确了解生产截面。在本文中，我们报告了在伯尔尼大学医院回旋加速器实验室对富集GdO、GdO和GdO靶进行质子辐照所形成的铽及其他铽放射性核素的生产截面测量结果。根据所得结果，计算了生产产率和纯度，以评估最佳辐照条件。还展示了几次生产测试的结果。
