Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
Phytochemistry. 2019 Jan;157:64-70. doi: 10.1016/j.phytochem.2018.10.008. Epub 2018 Oct 24.
Five undescribed xanthones, 4-methoxypyranojacareubin, 4-hydroxy-3-prenylpyranoxanthone, 1-hydroxy-5,7-dimethoxyxanthone, 5-hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone, together with thirty-three known xanthones were isolated from the roots of Mesua ferrea L. The structures of all isolated xanthones were elucidated based on spectroscopic methods. 5-Hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone were also confirmed by X-ray diffraction data. In addition, the isolated compounds were determined for antibacterial, antioxidant and cytotoxic activities. The known 1,5,6-trihydroxyxanthone showed cytotoxicity against A375, PC-3 and HaCaT cell lines with IC values of 5.73 μg/mL, 5.93 μg/mL and 8.94 μg/mL, respectively.
从麻疯树的根部分离得到了五个未被描述的紫檀烷酮，包括 4-甲氧基吡喃乔卡雷宾、4-羟基-3-烯丙基吡喃氧杂酮、1-羟基-5,7-二甲氧基紫檀烷酮、5-羟基-1,6,7-三甲氧基紫檀烷酮和 2-羟基-1,5-二甲氧基紫檀烷酮，以及三十三个已知的紫檀烷酮。基于光谱方法确定了所有分离出的紫檀烷酮的结构。5-羟基-1,6,7-三甲氧基紫檀烷酮和 2-羟基-1,5-二甲氧基紫檀烷酮也通过 X 射线衍射数据得到了确认。此外，还测定了分离得到的化合物的抗菌、抗氧化和细胞毒性活性。已知的 1,5,6-三羟基紫檀烷酮对 A375、PC-3 和 HaCaT 细胞系表现出细胞毒性，IC 值分别为 5.73μg/mL、5.93μg/mL 和 8.94μg/mL。
