Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.
Environ Sci Pollut Res Int. 2018 Dec;25(36):36394-36402. doi: 10.1007/s11356-018-3535-4. Epub 2018 Oct 28.
In this study, we investigated multi-generational effects and generation particle transfer in Caenorhabditis elegans following maternal food exposure to core-shell quantum dots. We found that that the Bag of Worms (BOW) phenotype in aged worms induces changes in quantum dot distribution in the parental body, which is related to the inter-generation transfer of these nanoparticles and to their effects in the offspring. To confirm these results we examined a variety of endpoints, namely, survival, reproduction, aging phenotype, oxidative stress, and intestinal fat metabolism. We show that worms born to parents at different times after exposure show different phenotypic effects as a consequence of quantum dot transfer. This evidence of trans-generational transfer and the effects of nanoparticles highlights the complex multi-generational effects and potential safety hazards that can occur under real environmental conditions.
在这项研究中，我们研究了母体食物暴露于核壳量子点后，秀丽隐杆线虫的多代效应和代间颗粒转移。我们发现，年老线虫的“蠕虫袋”（BOW）表型诱导了亲本体中量子点分布的变化，这与这些纳米颗粒的代间转移及其对后代的影响有关。为了证实这些结果，我们检查了各种终点，即生存、繁殖、衰老表型、氧化应激和肠道脂肪代谢。我们表明，暴露后不同时间出生的父母所生的蠕虫由于量子点转移而表现出不同的表型效应。这种跨代转移和纳米颗粒效应的证据突出了在真实环境条件下可能发生的复杂的多代效应和潜在的安全隐患。
