Korea University, Seoul, Korea.
The Johns Hopkins University, Baltimore, MD, USA.
Adv Exp Med Biol. 2018;1092:41-55. doi: 10.1007/978-3-319-95294-9_3.
Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be critical in cell migration, particularly in cancer invasion and metastasis. Moreover, to take a deeper look onto the oncologic relevance of the nucleus, there has been a shift in cell systems. That is, our understanding of nucleus does not stand alone but it is understood by the relationship between cell and its microenvironment in the in vivo-relevant 3D space.
核是一种专门的细胞器，充当着所有细胞行为的控制塔。虽然核信号的传统生化特征已经被揭示，但核系统的许多物理方面仍存在疑问。创新性的生物物理研究最近确定了机械调节途径，这些途径在细胞迁移中尤为重要，特别是在癌症的侵袭和转移中。此外，为了更深入地了解核的肿瘤学相关性，细胞系统发生了转变。也就是说，我们对核的理解不是孤立的，而是通过细胞与其在体内相关的 3D 空间中的微环境之间的关系来理解的。
