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结直肠癌的力学生物学

Mechanobiology of Colorectal Cancer.

作者信息

Brás Maria Manuela, Sousa Susana R, Carneiro Fátima, Radmacher Manfred, Granja Pedro L

机构信息

Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal.

Instituto de Engenharia Biomédica (INEB), Universidade do Porto, 4200-135 Porto, Portugal.

出版信息

Cancers (Basel). 2022 Apr 12;14(8):1945. doi: 10.3390/cancers14081945.

DOI:10.3390/cancers14081945
PMID:35454852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028036/
Abstract

In this review, the mechanobiology of colorectal cancer (CRC) are discussed. Mechanotransduction of CRC is addressed considering the relationship of several biophysical cues and biochemical pathways. Mechanobiology is focused on considering how it may influence epithelial cells in terms of motility, morphometric changes, intravasation, circulation, extravasation, and metastization in CRC development. The roles of the tumor microenvironment, ECM, and stroma are also discussed, taking into account the influence of alterations and surface modifications on mechanical properties and their impact on epithelial cells and CRC progression. The role of cancer-associated fibroblasts and the impact of flow shear stress is addressed in terms of how it affects CRC metastization. Finally, some insights concerning how the knowledge of biophysical mechanisms may contribute to the development of new therapeutic strategies and targeting molecules and how mechanical changes of the microenvironment play a role in CRC disease are presented.

摘要

在本综述中，讨论了结直肠癌（CRC）的力学生物学。考虑到几种生物物理线索与生化途径之间的关系，探讨了CRC的机械转导。力学生物学专注于研究其如何在CRC发展过程中，从运动性、形态计量学变化、血管内渗、循环、血管外渗和转移等方面影响上皮细胞。还讨论了肿瘤微环境、细胞外基质（ECM）和基质的作用，同时考虑了改变和表面修饰对力学性能的影响及其对上皮细胞和CRC进展的影响。从癌症相关成纤维细胞如何影响CRC转移的角度，阐述了其作用以及流动切应力的影响。最后，介绍了一些关于生物物理机制知识如何有助于开发新的治疗策略和靶向分子，以及微环境的力学变化如何在CRC疾病中发挥作用的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/86a2c42a0e61/cancers-14-01945-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/0ee71aac97fd/cancers-14-01945-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/5bc4810c930d/cancers-14-01945-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/2d1f6745ad2b/cancers-14-01945-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/e039858913b3/cancers-14-01945-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/cab584d40b94/cancers-14-01945-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/86a2c42a0e61/cancers-14-01945-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/0ee71aac97fd/cancers-14-01945-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/5bc4810c930d/cancers-14-01945-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/2d1f6745ad2b/cancers-14-01945-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/e039858913b3/cancers-14-01945-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/cab584d40b94/cancers-14-01945-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/9028036/86a2c42a0e61/cancers-14-01945-g006.jpg

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本文引用的文献

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mTOR Signaling Components in Tumor Mechanobiology.肿瘤机械生物学中的 mTOR 信号成分。
Int J Mol Sci. 2022 Feb 5;23(3):1825. doi: 10.3390/ijms23031825.
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Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.粘弹性作为肿瘤细胞外基质特征的标志物。
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Hippo Signaling Pathway in Colorectal Cancer: Modulation by Various Signals and Therapeutic Potential.结直肠癌中的 Hippo 信号通路：各种信号的调节及治疗潜力。
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Tumor Cell Communications as Promising Supramolecular Targets for Cancer Chemotherapy: A Possible Strategy.肿瘤细胞通讯作为癌症化疗有前途的超分子靶点：一种可能的策略。
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Fundamentals of Bowel Cancer for Biomedical Engineers.结直肠癌的生物医学工程基础。
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Editorial: Cancer Cell Mechanobiology - A New Frontier for Cancer Invasion and Metastasis Research.社论：癌细胞力学生物学——癌症侵袭与转移研究的新前沿
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AFM Force Relaxation Curve Reveals That the Decrease of Membrane Tension Is the Essential Reason for the Softening of Cancer Cells.原子力显微镜力松弛曲线表明，膜张力降低是癌细胞软化的根本原因。
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